Biochemistry (Moscow)

, Volume 80, Issue 11, pp 1418–1428 | Cite as

Mitochondrial matrix processes

  • I. O. MazuninEmail author
  • S. A. Levitskii
  • M. V. Patrushev
  • P. A. Kamenski


Mitochondria possess their own genome that, despite its small size, is critically important for their functioning, as it encodes several dozens of RNAs and proteins. All biochemical processes typical for bacterial and nuclear DNA are described in mitochondrial matrix: replication, repair, recombination, and transcription. Commonly, their mechanisms are similar to those found in bacteria, but they are characterized by several unique features. In this review, we provide an overall description of mitochondrial matrix processes paying special attention to the typical features of such mechanisms.


mitochondria mtDNA nucleoid transcription replication repair recombination 



base excision repair


mismatch repair


mitochondrial DNA


mitochondrial transcription termination factor


mitochondrial protein binding to single-stranded DNA


mitochondrial DNA polymerase


mitochondrial RNA polymerase


mitochondrial transcription factors A, B1 and B2


mitochondrial DNA helicase


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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • I. O. Mazunin
    • 1
    Email author
  • S. A. Levitskii
    • 2
  • M. V. Patrushev
    • 1
    • 2
  • P. A. Kamenski
    • 1
    • 2
  1. 1.Institute of Chemistry and BiologyImmanuil Kant Baltic Federal UniversityKaliningradRussia
  2. 2.Lomonosov Moscow State UniversityMoscowRussia

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