Biochemistry (Moscow)

, Volume 80, Issue 10, pp 1373–1386 | Cite as

Role of restriction-modification systems in prokaryotic evolution and ecology

  • A. S. Ershova
  • I. S. Rusinov
  • S. A. Spirin
  • A. S. Karyagina
  • A. V. Alexeevski
Review

Abstract

Restriction–modification (R-M) systems are able to methylate or cleave DNA depending on methylation status of their recognition site. It allows them to protect bacterial cells from invasion by foreign DNA. Comparative analysis of a large number of available bacterial genomes and methylomes clearly demonstrates that the role of R-M systems in bacteria is wider than only defense. R-M systems maintain heterogeneity of a bacterial population and are involved in adaptation of bacteria to change in their environmental conditions. R-M systems can be essential for host colonization by pathogenic bacteria. Phase variation and intragenomic recombinations are sources of the fast evolution of the specificity of R-M systems. This review focuses on the influence of R-M systems on evolution and ecology of prokaryotes.

Keywords

restriction-modification systems DNA methyltransferase restriction endonuclease horizontal gene transfer epigenetics bacteria DNA methylation 

Abbreviation

bp

base pairs

MTase

DNA-methyltransferase

REase

restriction endonuclease

R-M system

restriction–modification system

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • A. S. Ershova
    • 1
    • 2
    • 3
  • I. S. Rusinov
    • 1
    • 4
  • S. A. Spirin
    • 1
    • 4
    • 5
  • A. S. Karyagina
    • 1
    • 2
    • 3
  • A. V. Alexeevski
    • 1
    • 4
    • 5
  1. 1.Belozerksy Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Gamaleya Center of Epidemiology and MicrobiologyMoscowRussia
  3. 3.Institute of Agricultural BiotechnologyMoscowRussia
  4. 4.Faculty of Bioengineering and BioinformaticsLomonosov Moscow State UniversityMoscowRussia
  5. 5.Institute of System StudiesMoscowRussia

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