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Possible role of proteases in preconditioning of brain cells to pathological conditions

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Abstract

Preconditioning (PC) is one of the most effective strategies to reduce the severity of cell damage, in particular of nervous tissue cells. Although PC mechanisms are studied insufficiently, it is clear that proteases are involved in them, but their role has yet been not studied in detail. In this work, some mechanisms of a potential recruiting of proteases in PC are considered. Our attention is mainly focused on the protease families of caspases and cathepsins and on protease receptors. We present evidence that just these proteins are involved in the PC of brain cells. A hypothesis is proposed that secreted cathepsin B is involved in the realization of PC through activation of PAR2 receptor.

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Abbreviations

AP:

autophagy

IPC:

ischemic preconditioning

PC:

preconditioning

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Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485, Moscow, Russia

    A. A. Yakovlev & N. V. Gulyaeva

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  1. A. A. Yakovlev
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  2. N. V. Gulyaeva
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Correspondence to N. V. Gulyaeva.

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Original Russian Text © A. A. Yakovlev, N. V. Gulyaeva, 2015, published in Biokhimiya, 2015, Vol. 80, No. 2, pp. 204–213.

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Yakovlev, A.A., Gulyaeva, N.V. Possible role of proteases in preconditioning of brain cells to pathological conditions. Biochemistry Moscow 80, 163–171 (2015). https://doi.org/10.1134/S0006297915020030

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  • DOI: https://doi.org/10.1134/S0006297915020030

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