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Biochemistry (Moscow)

, Volume 79, Issue 13, pp 1635–1652 | Cite as

Human herpes simplex virus: Life cycle and development of inhibitors

  • M. K. Kukhanova
  • A. N. KorovinaEmail author
  • S. N. Kochetkov
Review

Abstract

WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.

Key words

HSV herpes simplex life cycle replication drugs mutations resistance 

Abbreviations

ACV

acyclovir

AraA

adenine arabinoside

BVDU

(E)-5-(2-bromovinyl)-2′-deoxyuridine (brivudin)

CMV

cytomegalovirus

DAI

DNA-dependent activator of interferon regulatory factor

GCV

ganciclovir

HFC-1

host cell factor 1

HHV-6A, 6B, 7, 8

human herpes virus

HIV

human immunodeficiency virus

HpACV

acyclovir H-phosphonate

HSV-1

herpes simplex virus-1

IFI16

γ-interferon-inducible protein

IRF-3

interferon regulatory factor 3

LAT

latency associated transcript

ND-10

nuclear domain 10

PCV

penciclovir

PFA

phosphonoformic acid

PMEA

9-(2-phosphonylmethoxyethyl)-adenine

RR

ribonucleotide reductase

VZV

varicella zoster virus

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • M. K. Kukhanova
    • 1
  • A. N. Korovina
    • 1
    Email author
  • S. N. Kochetkov
    • 1
  1. 1.Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia

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