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Biochemistry (Moscow)

, Volume 79, Issue 10, pp 1130–1132 | Cite as

Therapeutic doses of SkQ1 do not induce cytochromes P450 in rat liver

  • K. N. MyasoedovaEmail author
  • D. N. Silachev
Review

Abstract

The effect of SkQ1 (a mitochondria-targeted antioxidant) on the level of cytochromes P450 in rat liver was studied. It was found that administration of therapeutic dose of SkQ1 with drinking water for 5 days (250 nmol/kg of body weight per day) did not alter the level of cytochromes P450. Under the same conditions, the standard dose of phenobarbital used for the induction of cytochromes P450 caused the 2.7-fold increase in the content of these cytochromes. We conclude that therapeutic doses of SkQ1 do not induce cytochromes P450 in rats.

Key words

cytochrome P450 mitochondria-targeted antioxidant SkQ1 

Abbreviations

SkQ1

plastoquinonyl-decyltriphenylphosphonium

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  1. 1.Faculty of Fundamental MedicineLomonosov Moscow State UniversityMoscowRussia
  2. 2.Institute of MitoengineeringLomonosov Moscow State UniversityMoscowRussia
  3. 3.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia

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