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Biochemistry (Moscow)

, Volume 79, Issue 9, pp 928–946 | Cite as

Use of intracellular transport processes for targeted drug delivery into a specified cellular compartment

  • A. A. Rosenkranz
  • A. V. Ulasov
  • T. A. Slastnikova
  • Y. V. Khramtsov
  • A. S. SobolevEmail author
Review

Abstract

Targeted drug delivery into the cell compartment that is the most vulnerable to effects of the corresponding drug is a challenging problem, and its successful solution can significantly increase the efficiency and reduce side effects of the delivered therapeutic agents. To accomplish this one can utilize natural mechanisms of cellular specific uptake of macromolecules by receptor-mediated endocytosis and intracellular transport between cellular compartments. A transporting construction combining the components responsible for different steps of intracellular transport is promising for creating multifunctional modular constructions capable of delivering the necessary therapeutic agent into a given compartment of type-specified cells. This review focuses on intracellular transport peculiarities along with approaches for designing such transporting constructions for new, more effective, and safer strategies for treatment of various diseases.

Key words

targeted drug delivery intracellular transport receptor-mediated endocytosis transport of macromolecules nuclear import modular nanotransporters cancer therapy 

Abbreviations

CPP

cell penetration peptides

HMP

hemoglobin-like protein of E. coli

MNT

modular nanotransporters

NES

nuclear export signal

NLS

nuclear localization signal

PAA

polyamidoamine

PEI

polyethyleneimine

PS

photosensitizer

ROS

reactive oxygen species

TAT

trans-activator of transcription

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • A. A. Rosenkranz
    • 1
    • 2
  • A. V. Ulasov
    • 1
    • 3
  • T. A. Slastnikova
    • 1
  • Y. V. Khramtsov
    • 1
  • A. S. Sobolev
    • 1
    • 2
    Email author
  1. 1.Institute of Gene BiologyRussian Academy of SciencesMoscowRussia
  2. 2.Faculty of BiologyLomonosov Moscow State UniversityMoscowRussia
  3. 3.Targeted Delivery of Pharmaceuticals “Translek” LLCMoscowRussia

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