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Biochemistry (Moscow)

, Volume 79, Issue 7, pp 608–618 | Cite as

Nuclear matrix and structural and functional compartmentalization of the eucaryotic cell nucleus

  • S. V. RazinEmail author
  • V. V. Borunova
  • O. V. Iarovaia
  • Y. S. Vassetzky
Review

Abstract

Becoming popular at the end of the 20th century, the concept of the nuclear matrix implies the existence of a nuclear skeleton that organizes functional elements in the cell nucleus. This review presents a critical analysis of the results obtained in the study of nuclear matrix in the light of current views on the organization of the cell nucleus. Numerous studies of nuclear matrix have failed to provide evidence of the existence of such a structure. Moreover, the existence of a filamentous structure that supports the nuclear compartmentalization appears to be unnecessary, since this function is performed by the folded genome itself.

Key words

nuclear matrix chromatin functional compartmentalization of cell nucleus architecture of interphase chromosomes interchromatin domain DNA loops 

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • S. V. Razin
    • 1
    • 2
    • 3
    Email author
  • V. V. Borunova
    • 3
  • O. V. Iarovaia
    • 1
    • 2
  • Y. S. Vassetzky
    • 2
    • 4
  1. 1.Institute of Gene BiologyRussian Academy of SciencesMoscowRussia
  2. 2.LIA 1066 French-Russian Joint Cancer Research LaboratoryMoscowRussia
  3. 3.Faculty of BiologyLomonosov Moscow State UniversityMoscowRussia
  4. 4.UMR8126Université Paris-Sud, CNRS, Institut de Cancérologie Gustave RoussyVillejuifFrance

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