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Biochemistry (Moscow)

, Volume 79, Issue 7, pp 581–592 | Cite as

Age-related obesity is a heritage of the evolutionary past

  • E. V. TereshinaEmail author
  • S. I. Ivanenko
Review

Abstract

In the process of human aging, an increase in the total amount of fat is observed mainly due to accumulation of lipids in non-adipose tissues. Insulin resistance, provoked by the intracellular accumulation of triglycerides, is often associated with development of such age-related diseases as atherosclerosis, type 2 diabetes, cancer, osteoporosis, and also with systemic inflammation and lipo- and glucose toxicity. Accumulation of lipids and lipophilic compounds is a biological phenomenon common for both prokaryotes and eukaryotes. Initially, it arose as an adaptation to starvation and shortage of nitrogen-containing nutrients, but later it converted into a depot of membrane material, needed on recommencement of cell division. In rodents and humans, the accumulation of non-metabolized fat in non-adipose tissues can be regarded as an adaptation to changes in the internal medium on a certain stage of ontogenesis as a result of age-related dysfunction of adipose tissue.

Key words

lipid accumulation adaptation adipose tissue lipotoxicity aging 

Abbreviations

AMPK

AMP kinase

DGAT

acyl-CoA diglyceride acyltransferase

FA

fatty acids

FAT

fatty acid transporter

FATBP

fatty acid transporter-binding protein

FATP

fatty acid transport protein

IGF-1

insulin-like growth factor-1

PPAR

peroxisome proliferator-activated receptor

SCD

stearoyl-CoA desaturase

SREBP-1c

sterol regulatory element-binding protein-1c

VLDL

very low density lipoproteins

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  1. 1.World Wide Medical AssistanceOberwill ZugSwitzerland
  2. 2.Pirogov Russian State Medical UniversityRussian Scientific and Clinical Center of GerontologyMoscowRussia

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