Biochemistry (Moscow)

, Volume 79, Issue 5, pp 397–405 | Cite as

Dynorphins in regulation of immune system functions

  • S. V. GeinEmail author


Dynorphins constitute a family of opioid peptides manifesting the highest affinity for κ-opiate receptors. Immune system cells are known to express a κ-receptor similar to that in the central nervous system, and as a consequence dynorphins are involved in the interaction between cells of the nervous and immune systems. In this review, data on dynorphin structure are analyzed and generalized, the κ-opiate receptor is characterized, and data on the regulation by dynorphins of functioning of the innate and adaptive immunity cells are summarized.

Key words

dynorphin κ-opiate receptor immunoregulatory effects monocytes/macrophages lymphocytes NK-cells dendritic cells cAMP 





apoptosis-regulated kinase


cyclic adenosine monophosphate


CREB-binding protein


central nervous system


cAMP-response element-binding transcriptional factor




downstream regulatory element


extracellular loop


endoplasmic reticulum


extracellularly-regulated kinases


G-protein-coupled receptors


human immunodeficiency virus


nociceptin/orphanin FQ


interferon γ






inositol triphosphate


c-Jun N-terminal protein kinases




mitogen-activated protein kinases


nuclear factor κB


nerve growth factor-induced


natural killers


N-methyl-D-aspartate (non-opioid receptor for dynorphin A)


nor-binaltorphimine hydrochloride




phosphatidylinositol bisphosphate


protein kinase A


protein kinase C


phospholipase C


specific protein 1


non-receptor tyrosine kinase


TGF-β-regulated kinase


tumor necrosis factor α


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© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  1. 1.Institute of Ecology and Genetics of MicroorganismsUral Branch of the Russian Academy of SciencesPermRussia
  2. 2.Perm State UniversityPermRussia

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