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Biochemistry (Moscow)

, Volume 79, Issue 5, pp 397–405 | Cite as

Dynorphins in regulation of immune system functions

  • S. V. GeinEmail author
Review

Abstract

Dynorphins constitute a family of opioid peptides manifesting the highest affinity for κ-opiate receptors. Immune system cells are known to express a κ-receptor similar to that in the central nervous system, and as a consequence dynorphins are involved in the interaction between cells of the nervous and immune systems. In this review, data on dynorphin structure are analyzed and generalized, the κ-opiate receptor is characterized, and data on the regulation by dynorphins of functioning of the innate and adaptive immunity cells are summarized.

Key words

dynorphin κ-opiate receptor immunoregulatory effects monocytes/macrophages lymphocytes NK-cells dendritic cells cAMP 

Abbreviations

AP1

protein-activator-1

ASK1

apoptosis-regulated kinase

cAMP

cyclic adenosine monophosphate

CBP

CREB-binding protein

CNS

central nervous system

CREB

cAMP-response element-binding transcriptional factor

DAG

diacylglycerol

DRE

downstream regulatory element

ELC

extracellular loop

ER

endoplasmic reticulum

ERK

extracellularly-regulated kinases

GPCR

G-protein-coupled receptors

HIV

human immunodeficiency virus

H/OFQ

nociceptin/orphanin FQ

IFN-γ

interferon γ

Ig

immunoglobulin

IL

interleukin

IP2

inositol triphosphate

JUNK

c-Jun N-terminal protein kinases

LPS

lipopolysaccharide

MAPK

mitogen-activated protein kinases

NF-κB

nuclear factor κB

NGFI

nerve growth factor-induced

NK

natural killers

NMDA

N-methyl-D-aspartate (non-opioid receptor for dynorphin A)

nor-BNI

nor-binaltorphimine hydrochloride

PHA

phytohemagglutinin

PIP2

phosphatidylinositol bisphosphate

PKA

protein kinase A

PKC

protein kinase C

PLC

phospholipase C

SP1

specific protein 1

Src

non-receptor tyrosine kinase

TAK1

TGF-β-regulated kinase

TNF-α

tumor necrosis factor α

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  1. 1.Institute of Ecology and Genetics of MicroorganismsUral Branch of the Russian Academy of SciencesPermRussia
  2. 2.Perm State UniversityPermRussia

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