Biochemistry (Moscow)

, Volume 78, Issue 13, pp 1377–1391

Poly(A)-binding proteins: Structure, domain organization, and activity regulation

  • I. A. Eliseeva
  • D. N. Lyabin
  • L. P. Ovchinnikov


RNA-binding proteins are of vital importance for mRNA functioning. Among these, poly(A)-binding proteins (PABPs) are of special interest due to their participation in virtually all mRNA-dependent events that is caused by their high affinity for A-rich mRNA sequences. Apart from mRNAs, PABPs interact with many proteins, thus promoting their involvement in cellular events. In the nucleus, PABPs play a role in polyadenylation, determine the length of the poly(A) tail, and may be involved in mRNA export. In the cytoplasm, they participate in regulation of translation initiation and either protect mRNAs from decay through binding to their poly(A) tails or stimulate this decay by promoting mRNA inter-actions with deadenylase complex proteins. This review presents modern notions of the role of PABPs in mRNA-dependent events; peculiarities of regulation of PABP amount in the cell and activities are also discussed.

Key words

PABPs mRNA translation poly(A) tail polyadenylation mRNA decay 



AU-rich element


adenine-rich autoregulatory sequence




cytoplasmic polyadenylation element


cytoplasmic polyadenylation element binding protein


cleavage and polyadenylation specificity factor


eukaryotic initiation factor


exon junction complex


eukaryotic release factor


interferon γ-activated inhibitor of translation


heterogeneous nuclear ribonucleoprotein


interferon γ


internal ribosome entry site


C-terminal domain of PABP


Musashi 1


nonsense mediated mRNA decay


poly(A)-binding proteins


PABP-interacting protein 1/2


PABP-interacting motif


PABP-dependent poly(A)-specific ribonuclease 2/3


poly(A) polymerase


poly(A)-specific ribonuclease


premature termination codon


RNA recognition motif


terminal oligopyrimidine track


upstream of N-ras


untranslated region


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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • I. A. Eliseeva
    • 1
  • D. N. Lyabin
    • 1
  • L. P. Ovchinnikov
    • 1
  1. 1.Institute of Protein ResearchRussian Academy of SciencesPushchino, Moscow RegionRussia

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