Biochemistry (Moscow)

, Volume 78, Issue 13, pp 1377–1391

Poly(A)-binding proteins: Structure, domain organization, and activity regulation

  • I. A. Eliseeva
  • D. N. Lyabin
  • L. P. Ovchinnikov
Review

Abstract

RNA-binding proteins are of vital importance for mRNA functioning. Among these, poly(A)-binding proteins (PABPs) are of special interest due to their participation in virtually all mRNA-dependent events that is caused by their high affinity for A-rich mRNA sequences. Apart from mRNAs, PABPs interact with many proteins, thus promoting their involvement in cellular events. In the nucleus, PABPs play a role in polyadenylation, determine the length of the poly(A) tail, and may be involved in mRNA export. In the cytoplasm, they participate in regulation of translation initiation and either protect mRNAs from decay through binding to their poly(A) tails or stimulate this decay by promoting mRNA inter-actions with deadenylase complex proteins. This review presents modern notions of the role of PABPs in mRNA-dependent events; peculiarities of regulation of PABP amount in the cell and activities are also discussed.

Key words

PABPs mRNA translation poly(A) tail polyadenylation mRNA decay 

Abbreviations

ARE

AU-rich element

ARS

adenine-rich autoregulatory sequence

Cp

ceruloplasmin

CPE

cytoplasmic polyadenylation element

CPEBP

cytoplasmic polyadenylation element binding protein

CPSF

cleavage and polyadenylation specificity factor

eIF

eukaryotic initiation factor

EJC

exon junction complex

eRF

eukaryotic release factor

GAIT-element

interferon γ-activated inhibitor of translation

hnRNP

heterogeneous nuclear ribonucleoprotein

IFN-γ

interferon γ

IRES

internal ribosome entry site

MLLE

C-terminal domain of PABP

Msi1

Musashi 1

NMD

nonsense mediated mRNA decay

PABPs

poly(A)-binding proteins

Paip1/2

PABP-interacting protein 1/2

PAM

PABP-interacting motif

PAN2/3

PABP-dependent poly(A)-specific ribonuclease 2/3

PAP

poly(A) polymerase

PARN

poly(A)-specific ribonuclease

PTC

premature termination codon

RRM

RNA recognition motif

TOP

terminal oligopyrimidine track

UNR

upstream of N-ras

UTR

untranslated region

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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • I. A. Eliseeva
    • 1
  • D. N. Lyabin
    • 1
  • L. P. Ovchinnikov
    • 1
  1. 1.Institute of Protein ResearchRussian Academy of SciencesPushchino, Moscow RegionRussia

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