Biochemistry (Moscow)

, Volume 78, Issue 7, pp 736–745 | Cite as

Desialylation of surface receptors as a new dimension in cell signaling

  • A. V. PshezhetskyEmail author
  • L. I. Ashmarina


Terminal sialic acid residues are found in abundance in glycan chains of glycoproteins and glycolipids on the surface of all live cells forming an outer layer of the cell originally known as glycocalyx. Their presence affects the molecular properties and structure of glycoconjugates, modifying their function and interactions with other molecules. Consequently, the sialylation state of glycoproteins and glycolipids has been recognized as a critical factor modulating molecular recognitions inside the cell, between the cells, between the cells and the extracellular matrix, and between the cells and certain exogenous pathogens. Until recently sialyltransferases that catalyze transfer of sialic acid residues to the glycan chains in the process of their biosynthesis were thought to be mainly responsible for the creation and maintenance of a temporal and spatial diversity of sialylated moieties. However, the growing evidence suggests that in mammalian cells, at least equally important roles belong to sialidases/neuraminidases, which are located on the cell surface and in intracellular compartments, and may either initiate the catabolism of sialoglycoconjugates or just cleave their sialic acid residues, and thereby contribute to temporal changes in their structure and functions. The current review summarizes emerging data demonstrating that mammalian neuraminidase 1, well known for its lysosomal catabolic function, is also targeted to the cell surface and assumes the previously unrecognized role as a structural and functional modulator of cellular receptors.

Key words

sialylation neuraminidase lysosome plasma membrane immune response cell growth insulin 



cathepsin A/protective protein


2,3-dehydro-2-deoxy-N-acetylneuraminic acid


elastin-binding protein


epidermal growth factor receptor


Fc receptors for immunoglobulin G






insulin-like growth factor II




interleukin 4


insulin receptor


lysosome associated membrane protein 1


low-density lipoprotein


LDL receptor




mucin 1

NEU1, −2, −3, −4

neuraminidase 1, −2, −3, −4


platelet-derived growth factor




sialic acid


sialic acid binding immunoglobulin-like lectins


smooth muscle cells


serine-tyrosine kinase


Toll-like receptor


very low density lipoprotein


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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  1. 1.Department of Medical GeneticsCHU Sainte-Justine Research CenterMontrealCanada
  2. 2.Departments of Pediatrics and BiochemistryUniversity of MontrealMontrealCanada
  3. 3.Department of Anatomy and Cell Biology, Faculty of MedicineMcGill UniversityMontrealCanada

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