Biochemistry (Moscow)

, Volume 78, Issue 5, pp 542–548 | Cite as

Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention

  • V. I. Kirpatovsky
  • E. Y. Plotnikov
  • I. S. Mudraya
  • S. A. Golovanov
  • V. V. Drozhzheva
  • R. A. Khromov
  • D. Y. Chernikov
  • V. P. Skulachev
  • D. B. Zorov
Article

Abstract

Acute urine retention is a frequent complication in patients with benign hyperplasia of the prostate gland. According to studies made on experimental animals and people, it is accompanied by the deterioration of the bladder blood supply. This study attempts to explore the relationship of intramural blood flow, production of reactive oxygen species, and functional state of the bladder detrusor in modeling of acute urine retention in rats, as well as the impact of mitochondria-targeted antioxidants (which are supposed to alleviate the effects of oxidative stress induced by experimental ischemia) on these parameters. The study showed beneficial effects of mitochondria-targeted antioxidant SkQR1 in preventing damage of the bladder caused by acute urinary retention, which suggests the therapeutic use of this type of compounds for the treatment of ischemic abnormalities of the urinary bladder.

Key words

ischemia oxidative stress urine retention urinary bladder mitochondria-targeted antioxidants SkQ mitochondria 

Abbreviations

AUR

acute urine retention

DCF

2,7-dichlorfluorescein

IG

ischemic group

ROS

reactive oxygen species

SkQR1

10-(6′-plastoquinonyl) decylrhodamine 19

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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • V. I. Kirpatovsky
    • 1
    • 2
  • E. Y. Plotnikov
    • 2
    • 3
  • I. S. Mudraya
    • 1
  • S. A. Golovanov
    • 1
  • V. V. Drozhzheva
    • 1
  • R. A. Khromov
    • 1
  • D. Y. Chernikov
    • 1
  • V. P. Skulachev
    • 2
    • 3
  • D. B. Zorov
    • 2
    • 3
  1. 1.Research Institute of UrologyRussian Ministry of HealthMoscowRussia
  2. 2.Scientific Research Institute of MitoengineeringLomonosov Moscow State UniversityMoscowRussia
  3. 3.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia

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