Biochemistry (Moscow)

, Volume 78, Issue 4, pp 325–334 | Cite as

Role of microRNAs in mechanisms of glioblastoma resistance to radio- and chemotherapy

  • Ph. A. KoshkinEmail author
  • D. A. Chistiakov
  • V. P. Chekhonin


Low-grade gliomas and multiform glioblastoma are characterized by highly pronounced anaplasia, malignization, proliferation, and invasiveness; moreover, they are highly resistant to chemo- and radiotherapy. The very low efficiency of traditional approaches in the treatment of patients with glioblastomas is due to the intensive invasive growth of the tumor resulting in deep infiltration of adjacent normal perivascular and nervous tissue and formation of areas of perineural infiltration differently remote from the tumor epicenter. MicroRNAs are key posttranscriptional regulators of gene activities, and their expression is markedly increased in tumors, in particular in gliomas. MicroRNAs have been shown to promote the growth, proliferation, migration, and survival of tumor stem and non-stem cells. However, a population of microRNA possessing antitumor effects is also detected in gliomas. As a rule, the expression of antitumor microRNAs is suppressed in tumors. In this review, we consider microRNAs, their influence on radio- and chemoresistance of gliomas, and prospects for their use as specific agents in targeted therapy of gliomas. The pool of these microRNAs has distinct therapeutic value, because on use in combined therapy it can decrease the resistance of glioma tumor stem cells to existing pharmaceuticals and improve the efficiency of radio- and chemotherapy.

Key words

microRNA brain tumors glioma chemotherapy radiotherapy targeted delivery 



ATP-binding cassette carriers


multiple drug resistance protein 1


ATP-binding cassette protein of G subfamily subunit 2


aryl hydrocarbon receptor


protein kinase B


protein kinase ATM


Bcl2-associated protein X


apoptosis regulator Bcl-2


protein responsible for DNA repair


protein responsible for repair of double-strain breaks


phosphatase with double specificity


homolog of viral oncogene of avian myelocytomatosis V-myc


excision repair proteins


chemokine receptor of type 4


gene encoding iodothyronine 5′-monoiodinase


gene encoding δ-like protein-1


DNA-dependent protein kinase


epidermal growth factor receptor


flap-endonuclease 1


homeodomain-inter-acting protein kinase 2

Ku70 and Ku80

parts of heterodimeric protein binding to DNA double-strand break ends

Lig1 and Lig4

DNA ligases 1 and 4, respectively


L1 cell adhesion molecule

LRRFIP1 (leucine-rich repeat flightless-interacting protein 1)

cytosolic nucleic acid-binding protein


mammary gland carcinoma cell line


multiple drug resistance


multiple drug resistance protein


multiform glioblastoma


a three-protein (Mre11-Rad50-Nbs1) DNA repair complex

MVP (major vault protein)

a new multidrug resistance associated protein


nuclear factor κB


family of transmembrane proteins with repeated extracellular EGF and DSL domains


inhibitor of cyclin-dependent kinase




a dual-specificity protein phosphatase


pregnane X receptor


homolog of RAD51 (S. cerevisiae) or homolog of RecA (E. coli)


homolog of RAD52


protein involved in chromatin remodeling

RAD55 and RAD57

proteins acting in complex with RAD51


replication factor C subunit-1


stromal growth factor-1


short hairpin RNAs


signal transducers and transcription activator


transforming growth factor β


metalloproteinase inhibitor 3


tumor stem cells


proteins involved in DNA repair


protein of DNA repair


vascular endothelium growth factor






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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • Ph. A. Koshkin
    • 1
    • 2
    Email author
  • D. A. Chistiakov
    • 1
  • V. P. Chekhonin
    • 1
    • 2
  1. 1.Department of Medical NanobiotechnologyN. I. Pirogov Russian National Research Medical UniversityMoscowRussia
  2. 2.Department of Fundamental and Applied NeurobiologySerbsky State Scientific Center for Social and Forensic PsychiatryMoscowRussia

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