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Biochemistry (Moscow)

, Volume 77, Issue 13, pp 1515–1535 | Cite as

New titin (connectin) isoforms and their functional role in striated muscles of mammals: Facts and suppositions

  • I. M. Vikhlyantsev
  • Z. A. Podlubnaya
Review

Abstract

This review summarizes results of our studies on titin isoform composition in vertebrate striated muscles under normal conditions, during hibernation, real and simulated microgravity, and under pathological conditions (stiff-person syndrome, post-apoplectic spasticity, dilated cardiomyopathy, cardiac hypertrophy). Experimental evidence for the existence in mammalian striated muscles of higher molecular weight isoforms of titin (NT-isoforms) in addition to the known N2A-, N2BA-, and N2B-titin isoforms was obtained. Comparative studies of changes in titin isoform composition and structure-functional properties of human and animal striated muscles during adaptive and pathological processes led to a conclusion about the key role of NT-isoforms of titin in maintenance of sarcomere structure and contractile function of these muscles.

Key words

skeletal and cardiac muscles NT- N2A- N2BA- and N2B-isoforms of titin T2-fragment hibernation microgravity stiff-person syndrome post-apoplectic spasticity dilated cardiomyopathy cardiac hypertrophy spontaneously hypertensive rats (SHR) 

Abbreviations

cDNA

complementary deoxyribonucleic acid

DCM

dilated cardiomyopathy

LV

left ventricle of heart

MHC

myosin heavy chains

SHR

spontaneously hypertensive rats

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  1. 1.Institute of Theoretical and Experimental BiophysicsRussian Academy of SciencesPushchino, Moscow RegionRussia
  2. 2.Pushchino State Institute of Natural SciencesPushchino, Moscow RegionRussia

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