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Biochemistry (Moscow)

, Volume 77, Issue 9, pp 1044–1055 | Cite as

RETRACTED ARTICLE: Signaling pathways in tumor vasculogenic mimicry

  • A. A. VartanianEmail author
Regular Articles Review

Abstract

Solid tumor growth is dependent on the development of an adequate blood supply. For years, sprouting angiogenesis has been considered as the exclusive mechanism of tumor vascularization. However, in recent years, another mechanism of tumor vascularization has been identified that does not involve endothelial cells, a process called vasculogenic mimicry (VM). VM describes the unique ability of highly aggressive tumor cells to form vessel-like networks by virtue of their high plasticity. VM has been observed in several tumor types, and its occurrence is strongly associated with poor prognosis. This review focuses on signaling molecules and cascades involved in VM. In addition, the clinical significance of VM regardless of anti-angiogenesis treatment modalities is described.

Key words

highly aggressive tumor vasculogenic mimicry signaling pathway prognosis 

Abbreviations

AOs

antioxidants

CLS

capillary-like structures

ECs

endothelial cells

ROS

reactive oxygen species

TCs

tumor cells

TSCs

tumor stem cells

VM

vasculogenic mimicry

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  1. 1.Institute of Experimental Diagnosis and Biotherapy of Tumors, Blokhin Russian Cancer Research CenterRussian Academy of Medical SciencesMoscowRussia

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