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Biochemistry (Moscow)

, Volume 77, Issue 9, pp 996–999 | Cite as

Mitochondria-targeted plastoquinone antioxidant SkQR1 decreases trauma-induced neurological deficit in rat

  • N. K. IsaevEmail author
  • S. V. Novikova
  • E. V. Stelmashook
  • I. V. Barskov
  • D. N. Silachev
  • L. G. Khaspekov
  • V. P. Skulachev
  • D. B. Zorov
Article

Abstract

A protective effect of a mitochondria-targeted antioxidant, a cationic rhodamine derivative linked to a plastoquinone molecule (10-(6′-plastoquinonyl)decylrhodamine-19, SkQR1) was studied in the model of open focal trauma of rat brain sensorimotor cortex. It was found that daily intraperitoneal injections of SkQR1 (100 nmol/kg) for 4 days after the trauma improved performance in a test characterizing neurological deficit and decreased the volume of the damaged cortical area. Our results suggest that SkQR1 exhibits profound neuroprotective effect, which may be explained by its antioxidative activity.

Key words

brain trauma neuroprotection mitochondria-targeted antioxidants SkQR1 

Abbreviations

MMP

mitochondrial membrane permeabilization (nonspecific permeability of the inner mitochondrial membrane)

ROS

reactive oxygen species

SkQR1

10-(6′-plastoquinonyl)decylrhodamine-19

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • N. K. Isaev
    • 1
    • 2
    • 3
    Email author
  • S. V. Novikova
    • 2
    • 3
  • E. V. Stelmashook
    • 2
    • 3
  • I. V. Barskov
    • 2
  • D. N. Silachev
    • 1
    • 3
  • L. G. Khaspekov
    • 2
  • V. P. Skulachev
    • 1
    • 3
  • D. B. Zorov
    • 1
    • 3
  1. 1.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Research Center of NeurologyRussian Academy of Medical SciencesMoscowRussia
  3. 3.Institute of MitoengineeringLomonosov Moscow State UniversityMoscowRussia

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