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Biochemistry (Moscow)

, Volume 77, Issue 8, pp 813–819 | Cite as

MicroRNAs: Possible role in pathogenesis of Parkinson’s disease

  • E. V. Filatova
  • A. Kh. AlievaEmail author
  • M. I. Shadrina
  • P. A. Slominsky
Review

Abstract

Parkinson’s disease is one of the most common human neurodegenerative disorders caused by the loss of dopaminergic neurons from the substantia nigra pars compacta of human brain. However, causes and mechanisms of the progression of the disease are not yet fully clarified. To date, investigation of the role of miRNAs in norm and pathology is one of the most intriguing and actively developing areas in molecular biology. MiRNAs regulate expression of a variety of genes and can be implicated in pathogenesis of various diseases. Possible role of miRNAs in pathogenesis of Parkinson’s disease is discussed in this review.

Key words

microRNA Parkinson’s disease miRNA-dependent regulation 

Abbreviations

DA-neuron

dopaminergic neuron

NDD

neurodegenerative disease

PD

Parkinson’s disease

SNP

single nucleotide polymorphism

UTR

untranslated region

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • E. V. Filatova
    • 1
  • A. Kh. Alieva
    • 1
    Email author
  • M. I. Shadrina
    • 1
  • P. A. Slominsky
    • 1
  1. 1.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia

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