The current view on phenoptosis and apoptosis as genetic programs aimed at eliminating potentially dangerous organisms and cells, respectively, is given. Special emphasis is placed on apoptosis (phenoptosis) in yeasts: intracellular defects and a plethora of external stimuli inducing apoptosis in yeasts; distinctive morphological and biochemical hallmarks accompanying apoptosis in yeasts; pro- and antiapoptotic factors involved in yeast apoptosis signaling; consecutive stages of apoptosis from external stimulus to the cell death; a prominent role of mitochondria and other organelles in yeast apoptosis; possible pathways for release of apoptotic factors from the intermembrane mitochondrial space into the cytosol are described. Using some concrete examples, the obvious physiological importance and expediency of altruistic death of yeast cells is shown. Poorly known aspects of yeast apoptosis and prospects for yeast apoptosis study are defined.
Key wordsyeasts phenoptosis apoptosis mitochondria endoplasmic reticulum vacuole
apoptosis inducing factor
AIF-homologous mitochondrion-associated inducer of death
located in the intermembrane space high temperature required protease A
protein, inhibitor of apoptosis
- mPTP (mitochondrial permeability transition pore)
nonspecific permeability of the inner mitochondrial membrane
reactive oxygen species
yeast mitochondrial unspecific channel
- Ysp1p and Ysp2p
mitochondrial yeast suicide proteins
Unable to display preview. Download preview PDF.