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Biochemistry (Moscow)

, Volume 77, Issue 6, pp 666–670 | Cite as

Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss

  • S. S. Jankauskas
  • E. Y. PlotnikovEmail author
  • M. A. Morosanova
  • I. B. Pevzner
  • L. D. Zorova
  • V. P. Skulachev
  • D. B. ZorovEmail author
Article

Abstract

The influence of the mitochondria-targeted antioxidant SkQR1 on gentamycin-induced nephrotoxicity and ototoxicity has been analyzed. SkQR1 reduces the death of kidney epithelium cells and decreases the severity of renal failure caused by gentamycin application and also lowers the animals’ mortality. Treatment with SkQR1 also decreases gentamycininduced hearing loss. Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics.

Key words

kidney organ of Corti mitochondria antioxidant nephrotoxicity ototoxicity antibiotics 

Abbreviations

AKI

acute kidney injury

ROS

reactive oxygen species

SkQR1

10-(6′-plastoquinonyl) decylrhodamine 19

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • S. S. Jankauskas
    • 1
    • 3
  • E. Y. Plotnikov
    • 2
    • 3
    Email author
  • M. A. Morosanova
    • 1
    • 3
  • I. B. Pevzner
    • 1
    • 3
  • L. D. Zorova
    • 3
    • 4
  • V. P. Skulachev
    • 1
    • 2
    • 3
  • D. B. Zorov
    • 2
    • 3
    Email author
  1. 1.Faculty of Bioengineering and BioinformaticsLomonosov Moscow State UniversityMoscowRussia
  2. 2.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia
  3. 3.Research Institute of MitoengineeringLomonosov Moscow State UniversityMoscowRussia
  4. 4.International Laser CenterLomonosov Moscow State UniversityMoscowRussia

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