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Biochemistry (Moscow)

, Volume 77, Issue 6, pp 648–658 | Cite as

SkQ1 slows development of age-dependent destructive processes in retina and vascular layer of eyes of wistar and OXYS rats

  • V. B. Saprunova
  • M. A. Lelekova
  • N. G. Kolosova
  • L. E. Bakeeva
Article

Abstract

We show the development of clearly pronounced age-related pathological changes in eye tissues of Wistar and OXYS rats. Photoreceptor cells were virtually absent in all OXYS rats in the age of 24 months. Massive accumulations of lipofuscin granules were detected in the pigmented epithelium cells. Flattening, overgrowing, and degradation of endothelial cells of choriocapillaries were also observed. Along with these changes, vessels without signs of degradation were detected in the pigmented epithelium. In 24-month-old Wistar rats these changes were local and were seen in only some of the animals. The mitochondria-targeted antioxidant SkQ1 (the rats were given SkQ1 daily with food at the dose of 250 nmol/kg for 5 months, starting from the age of 19 months) prevented the development of these pathological changes in both Wistar and OXYS rats. The data were subjected to mathematical processing and statistical analysis.

Key words

ultrastructure oxidative stress retina choriocapillary layer antioxidant 

Abbreviations

AMD

age-related macular degeneration

BM

Bruch’s membrane

CCL

choriocapillary layer

INL

inner nuclear layer

IRL

inner reticular layer

LG

lipofuscin granules

ONL

outer nuclear layer

ORL

outer reticular layer

PE

pigmented epithelium

PRL

photoreceptor layer

RL

rod layer

ROS

reactive oxygen species

RPE

retinal pigmented epithelium

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • V. B. Saprunova
    • 1
    • 2
  • M. A. Lelekova
    • 1
  • N. G. Kolosova
    • 2
    • 3
  • L. E. Bakeeva
    • 1
    • 2
  1. 1.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Institute of MitoengineeringLomonosov Moscow State UniversityMoscowRussia
  3. 3.Institute of Cytology and GeneticsSiberian Branch of the Russian Academy of SciencesNovosibirskRussia

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