Biochemistry (Moscow)

, Volume 77, Issue 4, pp 388–394 | Cite as

Metabolic dysfunction and relationship in human frontoparietal cortex in severe traumatic brain injury: Single-voxel 1H magnetic resonance spectroscopy study

  • N. A. SemenovaEmail author
  • T. A. Akhadov
  • A. V. Petryaykin
  • S. S. Sidorin
  • A. V. Lukovenkov
  • S. D. Varfolomeev


1H-magnetic resonance spectroscopy revealed that apparently normal (from the data of magnetic resonance imaging) human brain frontoparietal cortex in the subacute stage of traumatic brain injury is characterized by decreased level of N-acetylaspartate (NAA) and increase in levels of myoinositol, choline-containing compounds (Cho), and creatine/phosphocreatine (Cr). Correlations between Cr, Cho, and NAA were established. We propose a scheme of neuronal metabolic processes that joins these substances.

Key words

magnetic resonance spectroscopy severe traumatic brain injury frontoparietal cortex 



choline-containing compounds




diffuse axonal injury


Glasgow coma scale








magnetic resonance spectroscopy


magnetic resonance imaging








traumatic brain injury


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Soares, D. P., and Law, M. (2009) Clin. Radiol., 64, 12–21.PubMedCrossRefGoogle Scholar
  2. 2.
    Xin, L., Frenkel, H., Mlynarik, V., Morgenthaler, F. D., and Gruetter, R. (2009) Magn. Reson. Med., 61, 260–266.PubMedCrossRefGoogle Scholar
  3. 3.
    Ross, B. D., Bluml, S., Cowan, R., Danielsen, E. R., Farrow, N., and Gruetter, R. (1997) Biophys. Chem., 68, 161–172.PubMedCrossRefGoogle Scholar
  4. 4.
    Brand, A., Richter-Landsberg, C., and Leibfritz, D. (1993) Dev. Neurosci., 15, 289–298.PubMedCrossRefGoogle Scholar
  5. 5.
    Baslow, M., and Guilfoyle, D. (2006) in N-Acetylaspartate: a Unique Neuronal Molecule in the Central Nervous System (Moffet, J., Tieman, S., Weinberger, D., Coyle, J., and Namboodiri, A. M. A., eds.) Springer Science, N. Y., pp. 95–113.Google Scholar
  6. 6.
    Tran, T., Ross, B., and Lin, A. (2009) Clin. Neurol. Neurosurg., 27, 21–60.Google Scholar
  7. 7.
    Bonavita, S., Di Salle, F., and Tedeschi, G. (1999) Eur. J. Radiol., 30, 125–131.PubMedCrossRefGoogle Scholar
  8. 8.
    Sinson, G., Bagley, L. J., Cecil, K. M., Torchia, M., McGowan, J. C., Lenkinski, R. E., McIntosh, T. K., and Grossman, R. I. (2001) AJNR Am. J. Neuroradiol., 22, 143–151.PubMedGoogle Scholar
  9. 9.
    Hunter, J. V., Thornton, R. J., Wang, Z. J., Levin, H. S., Roberson, G., Brooks, W. M., and Swank, P. R. (2005) AJNR Am. J. Neuroradiol., 26, 482–488.PubMedGoogle Scholar
  10. 10.
    Ashwal, S., Babikian, T., Gardner-Nichols, J., Freier, M. C., Tong, K. A., and Holshouser, B. A. (2006) Arch. Phys. Med. Rehabil., 87, 50–58.CrossRefGoogle Scholar
  11. 11.
    Cohen, B. A., Inglese, M., Rusinek, H., Babb, J. S., Grossman, R. I., and Gonen, O. (2007) AJNR Am. J. Neuroradiol., 28, 907–913.PubMedGoogle Scholar
  12. 12.
    Rigotti, D. J., Inglese, M., and Gonen, O. (2007) AJNR Am. J. Neuroradiol., 28, 1843–1849.PubMedCrossRefGoogle Scholar
  13. 13.
    Holshouser, B. A., Tong, K. A., and Ashwal, S. (2005) AJNR Am. J. Neuroradiol., 26, 1276–1285.PubMedGoogle Scholar
  14. 14.
    Brooks, W. M., Friedman, S. D., and Gasparovic, C. (2001) J. Head Trauma Rehabil., 16, 149–164.PubMedCrossRefGoogle Scholar
  15. 15.
    Akhadov, T. A., Semenova, N. A., Sitnikov, S. L., Agrafonov, A. Yu., and Petryaikin, A. V. (2009) Med. Vizualizatsiya, 2, 117–122.Google Scholar
  16. 16.
    Marino, S., Ciurleo, R., Bramanti, P., Federico, A., and De Stefano, N. (2011) Neurocrit. Care, 14, 127–133.PubMedCrossRefGoogle Scholar
  17. 17.
    Yeo, R., Gasparovic, C., Merideth, F. L., Ruhl, D. A., Doezema, D., and Mayer, A. (2009) J. Neurotrauma, 26, 1635–1643.PubMedCrossRefGoogle Scholar
  18. 18.
    Ashwal, S., Holshouser, B., Tong, K., Serna, T., Osterdock, R., Gross, M., and Kido, D. (2004) J. Neurotrauma, 21, 1539–1552.PubMedCrossRefGoogle Scholar
  19. 19.
    Ashwal, S., Holshouser, B., Tong, K., Serna, T., Osterdock, R., Gross, M., and Kido, D. (2004) Pediatr. Res., 56, 630–638.PubMedCrossRefGoogle Scholar
  20. 20.
    Mamere, A. E., Saraiva, L. A., Matos, A. L., Carneiro, A. A., and Santos, A. C. (2009) AJNR Am. J. Neuroradiol., 30, 947–952.PubMedCrossRefGoogle Scholar
  21. 21.
    Ashwal, S., Holshouser, B. A., Shu, S. K., Simmons, P. L., Perkin, R. M., Tomasi, L. G., Knierim, D. S., Sheridan, C., Craig, K., Andrews, G. H., and Hinshaw, D. B. (2000) Pediatr. Neurol., 23, 114–125.PubMedCrossRefGoogle Scholar
  22. 22.
    Aaen, G. S., Holshouser, B. A., Sheridan, C., Colbert, C., McKenney, M., Kido, D., and Ashwal, S. (2010) Pediatrics, 125, 295–303.PubMedCrossRefGoogle Scholar
  23. 23.
    Marino, S., Zei, E., Battaglini, M., Vittori, C., Buscalferri, A., Bramanti, P., Federico, A., and De Stefano, N. (2007) J. Neurol. Neurosurg. Psychiatry, 78, 501–507.PubMedCrossRefGoogle Scholar
  24. 24.
    Schuhmann, M. U., Stiller, D., Skardelly, M., Bernarding, J., Klinge, P. M., Samii, A., Samii, M., and Brinker, T. (2003) J. Neurotrauma, 20, 725–743.PubMedCrossRefGoogle Scholar
  25. 25.
    Signoretti, S., Marmarou, A., Tavazzi, B., Lazzarino, G., Beaumont, A., and Vagnozzi, R. (2001) J. Neurotrauma, 18, 977–991.PubMedCrossRefGoogle Scholar
  26. 26.
    Semenova, N. A., Varfolomeev, S. D., Akhadov, T. A., and Lukovenkov, A. V. (2011) Dokl. Biochem. Biophys., 436, 49–52.PubMedCrossRefGoogle Scholar
  27. 27.
    Guimaraes, A. R., Schwartz, P., Prakash, M. R., Carr, C. A., Berger, U. V., Jenkins, B. G., Coyle, J. T., and Gonzalez, R. G. (1995) Neurosciences, 69, 1095–1101.CrossRefGoogle Scholar
  28. 28.
    Braissant, O., Bachmann, C., and Henry, H. (2007) Subcell Biochem., 46, 67–81.PubMedCrossRefGoogle Scholar
  29. 29.
    Marret, V., Elkhalil, L., and Nazih-Sanderson, F. (1996) Biochem. J., 316, 805–811.Google Scholar
  30. 30.
    Sato, H., Hisayo, H., and Moriguchi, K. (1998) Biochem. Biophys. Res. Commun., 150, 491–496.CrossRefGoogle Scholar
  31. 31.
    Baslow, M. H., Hrabe, J., and Guilfoyle, D. N. (2007) J. Mol. Neurosci., 32, 235–245.PubMedCrossRefGoogle Scholar
  32. 32.
    Karp, G. (2009) Cell and Molecular Biology: Concepts and Experiments, Wiley, N. Y., p. 180.Google Scholar
  33. 33.
    Demougeot, C., Marie, C., Giroud, M., and Beley, A. (2004) J. Neurochem., 90, 776–801.PubMedCrossRefGoogle Scholar
  34. 34.
    Chadi, F., and Fuxe, K. (1998) Braz. J. Med. Biol. Res., 31, 231–241.PubMedCrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • N. A. Semenova
    • 1
    Email author
  • T. A. Akhadov
    • 2
  • A. V. Petryaykin
    • 2
  • S. S. Sidorin
    • 1
    • 2
  • A. V. Lukovenkov
    • 1
  • S. D. Varfolomeev
    • 1
  1. 1.Emanuel Institute of Biochemical PhysicsRussian Academy of SciencesMoscowRussia
  2. 2.Children’s Clinical and Research Institute of Emergency Surgery and TraumaMoscowRussia

Personalised recommendations