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Biochemistry (Moscow)

, Volume 77, Issue 4, pp 388–394 | Cite as

Metabolic dysfunction and relationship in human frontoparietal cortex in severe traumatic brain injury: Single-voxel 1H magnetic resonance spectroscopy study

  • N. A. SemenovaEmail author
  • T. A. Akhadov
  • A. V. Petryaykin
  • S. S. Sidorin
  • A. V. Lukovenkov
  • S. D. Varfolomeev
Article

Abstract

1H-magnetic resonance spectroscopy revealed that apparently normal (from the data of magnetic resonance imaging) human brain frontoparietal cortex in the subacute stage of traumatic brain injury is characterized by decreased level of N-acetylaspartate (NAA) and increase in levels of myoinositol, choline-containing compounds (Cho), and creatine/phosphocreatine (Cr). Correlations between Cr, Cho, and NAA were established. We propose a scheme of neuronal metabolic processes that joins these substances.

Key words

magnetic resonance spectroscopy severe traumatic brain injury frontoparietal cortex 

Abbreviations

Cho

choline-containing compounds

Cr

creatine/phosphocreatine

DAI

diffuse axonal injury

GCS

Glasgow coma scale

Glx

glutamine/glutamate

Lac

lactate

mI

myoinositol

MRS

magnetic resonance spectroscopy

MRI

magnetic resonance imaging

NAA

N-acetylaspartate

PCho

phosphocholine

SAM

S-adenosylmethionine

TBI

traumatic brain injury

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • N. A. Semenova
    • 1
    Email author
  • T. A. Akhadov
    • 2
  • A. V. Petryaykin
    • 2
  • S. S. Sidorin
    • 1
    • 2
  • A. V. Lukovenkov
    • 1
  • S. D. Varfolomeev
    • 1
  1. 1.Emanuel Institute of Biochemical PhysicsRussian Academy of SciencesMoscowRussia
  2. 2.Children’s Clinical and Research Institute of Emergency Surgery and TraumaMoscowRussia

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