Biochemistry (Moscow)

, Volume 77, Issue 2, pp 119–127 | Cite as

Structural and functional characteristics and properties of metzincins

  • N. P. Balaban
  • N. L. RudakovaEmail author
  • M. R. Sharipova


In this review the main families of endopeptidases belonging to the clan of metzincins of zinc-dependent metal-loproteinases in organisms of wide evolutional range from bacteria to mammals are considered. The data on classification, physicochemical properties, substrate specificity, and structural features of this group of enzymes are given. The activation mechanisms of metzincins, the role of these proteins in organisms, and their participation in various physiological processes are discussed.

Key words

metalloproteinases metzincins astacins adamalysins/reprolysins matrixins serralysins 


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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • N. P. Balaban
    • 1
  • N. L. Rudakova
    • 1
    Email author
  • M. R. Sharipova
    • 1
  1. 1.Kazan (Volga Region) Federal UniversityKazanRussia

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