Biochemistry (Moscow)

, Volume 77, Issue 1, pp 1–14 | Cite as

Molecular structure of phospholipase D and regulatory mechanisms of its activity in plant and animal cells

  • Y. S. Kolesnikov
  • K. P. Nokhrina
  • S. V. Kretynin
  • I. D. Volotovski
  • J. Martinec
  • G. A. Romanov
  • V. S. Kravets
Review

Abstract

Phospholipase D (PLD) catalyzes hydrolysis of phospholipids with production of phosphatidic acid, which often acts as secondary messenger of transduction of intracellular signals. This review summarizes data of leading laboratories on specific features of organization and regulation of PLD activity in plant and animal cells. The main structural domains of PLD (C2, PX, PH), the active site, and other functionally important parts of the enzyme are discussed. Regulatory mechanisms of PLD activity are characterized in detail. Studies associated with molecular design, analysis, and synthesis of new nontoxic substances capable of inhibiting different PLD isoenzymes in vivo are shown to be promising for biotechnology and medicine.

Key words

phospholipase D domains calcium lipids G-proteins protein kinases protein-protein interactions 

Abbreviations

α-subunit of heterotrimeric G-protein

PKC

protein kinase C

PLD

phospholipase D

PtdIns(4,5)P2

phosphatidylinositol-4,5-bisphosphate

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • Y. S. Kolesnikov
    • 1
  • K. P. Nokhrina
    • 2
  • S. V. Kretynin
    • 1
  • I. D. Volotovski
    • 3
  • J. Martinec
    • 4
  • G. A. Romanov
    • 5
  • V. S. Kravets
    • 1
  1. 1.Institute of Bioorganic Chemistry and PetrochemistryNational Academy of Sciences of UkraineKievUkraine
  2. 2.Plant Biotechnology InstituteNational Research Council of CanadaSaskatoonCanada
  3. 3.Institute of Biophysics and Cell EngineeringNational Academy of Sciences of BelarusMinskBelarus
  4. 4.Institute of Experimental BotanyAcademy of Sciences of the Czech RepublicPrague 6Czech Republic
  5. 5.Institute of Plant PhysiologyRussian Academy of SciencesMoscowRussia

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