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Biochemistry (Moscow)

, Volume 76, Issue 12, pp 1367–1370 | Cite as

In vivo injected mitochondria-targeted plastoquinone antioxidant SkQR1 prevents β-amyloid-induced decay of long-term potentiation in rat hippocampal slices

  • N. A. Kapay
  • N. K. Isaev
  • E. V. Stelmashook
  • O. V. Popova
  • D. B. Zorov
  • V. G. Skrebitsky
  • V. P. Skulachev
Short Communications

Abstract

Addition of 200 nM β-amyloid 1–42 (Abeta) to a rat hippocampal slice impairs the induction of a long-term post-tetanic potentiation (LTP) of population spike (PS) in pyramidal neurons of the CA1 field of hippocampus. Intraperitoneal injection into the rat of the mitochondria-targeted plastoquinone derivative SkQR1 (1 μmol/kg of weight given 24 h before the slices were made) abolishes the deleterious effect of Abeta on LTP. These data demonstrate that SkQR1 therapy is able to compensate the Abeta-induced impairments of long-term synaptic plasticity in the hippocampus, which are the main cause of loss of memory and other cognitive functions associated with Alzheimer’s disease.

Key words

Alzheimer’s disease β-amyloid long-term memory long-term potentiation neurons hippocampus mitochondria-targeted antioxidants SkQR1 

Abbreviations

Abeta

β-amyloid peptide 1–42

HFS

high frequency stimulation

LTP

long-term post-tetanic potentiation of hippocampal pathway

PS

population spike

ROS

reactive oxygen species

SkQR1

10-(6′-plastoquinonyl)decylrhodamine 19

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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • N. A. Kapay
    • 1
  • N. K. Isaev
    • 1
    • 2
    • 3
  • E. V. Stelmashook
    • 1
    • 3
  • O. V. Popova
    • 1
  • D. B. Zorov
    • 2
    • 3
  • V. G. Skrebitsky
    • 1
  • V. P. Skulachev
    • 2
    • 3
  1. 1.Department of Brain Research, Research Center of NeurologyRussian Academy of Medical SciencesMoscowRussia
  2. 2.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia
  3. 3.Institute of MitoengineeringLomonosov Moscow State UniversityMoscowRussia

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