Biochemistry (Moscow)

, 76:915 | Cite as

Identification of A-to-I RNA editing: Dotting the i’s in the human transcriptome

  • A. Kiran
  • G. Loughran
  • J. J. O’Mahony
  • P. V. Baranov
Review

Abstract

The phenomenon of adenosine-to-inosine (A-to-I) RNA editing has attracted considerable attention from the scientific community due to its potential relationship to the evolution of cognition in animals. While A-to-I editing exists in all organisms with neurons, including those with primitive neuronal systems (hydra and nematodes), it is particularly frequent in organisms with a highly developed central nervous system (primates, especially humans). Diversification of RNA transcript sequences via A-to-I editing serves a number of different functional roles, such as altering the genome-templated identity of particular amino acids in proteins or altering splice site junctions and modulating regulation of alternatively spliced mRNA variants. Here we provide an overview of current computational and experimental methods for the high-throughput discovery of edited RNA nucleotides in the human transcriptome, as well as a survey of the existing RNA editing bioinformatics resources and an outlook of future perspectives.

Key words

RNA editing A-to-I inosine RNA processing transcriptome diversity RNA sequencing human genome editome inosinome 

Supplementary material

10541_2011_9460_MOESM1_ESM.pdf (223 kb)
Supplementary material, approximately 222 KB.

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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • A. Kiran
    • 1
  • G. Loughran
    • 1
    • 2
  • J. J. O’Mahony
    • 1
  • P. V. Baranov
    • 1
  1. 1.Biochemistry DepartmentUniversity College CorkCorkIreland
  2. 2.BioSciences InstituteUniversity College CorkCorkIreland

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