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Biochemistry (Moscow)

, Volume 76, Issue 4, pp 394–406 | Cite as

Functional properties of extracellular domains of transducer receptor gp130

  • M. N. Kostjukova
  • N. N. TupitsynEmail author
Review
  • 77 Downloads

Abstract

Cytokine receptor molecules have been shown to have extracellular domains of complex structure and a multistep activation system. Glycoprotein gp130 is a typical transducer of cytokine signal; it functions by forming multicomponent receptor complexes and transferring signals of tens of cytokines from the IL-6 family. Structural organization and basic functioning principles of gp130 are well known, as well as related signal pathways, which function during normal differentiation and are involved in pathogenesis of many tumors. The role of gp130 in IL-6-dependent tumors is best studied. In this review, based on extensive accumulated data, we examine the functional significance of certain parts of gp130 extracellular domains. Potentials of a recently developed method for estimation of receptor activation at the level of epitope structure are discussed.

Key words

gp130 activation cytokine immunophenotyping monoclonal antibodies receptor structure IL-6 cytokine-binding homology region 

Abbreviations

CHR

cytokine-binding homology region

CLC

cardiotrophin-like cytokine

CNTF

ciliary neurotrophic factor

CNTFRα

ciliary neurotrophic factor receptor

CT-1

cardiotrophin-1

ELISA

enzyme-linked immunosorbent assay

HHV8 IL-6

interleukin-6 from human herpes virus type 8 genome

IgD

immunoglobulin-like domain

IL-6, -11,-27

interleukin 6, 11, 27

IL-6Rα

interleukin-6 receptor

JAK/STAT

signal cascade with participation of Janus-kinases (JAK) and signal transducers and activators of transcription (STAT)

LIF

leukemia inhibitory factor

LIFR (gp190)

leukemia inhibitory factor receptor

mAbs

monoclonal antibodies

NPN

neuropoietin

OSM

oncostatin M

PI3K/AKT

signal cascade with participation of phosphatidylinositol 3-kinase and protein kinase B (AKT)

Ras/MAP

signal cascade with participation of membrane-bound GTPase Ras and mitogen-activating kinases (MAP)

Rm IL-6

interleukin-6 from rhesus macaque adenovirus genome

SOCS

suppressor of cytokine signaling proteins

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Supplementary material

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References

  1. 1.
    Taga, T., and Kishimoto, T. (1997) Annu. Rev. Immunol., 15, 797–819.PubMedCrossRefGoogle Scholar
  2. 2.
    Heinrich, P. C., Behrmann, I., Muller-Newen, G., Schaper, F., and Graeve, L. (1998) Biochem. J., 334, 297–314.PubMedGoogle Scholar
  3. 3.
    Peters, M., Muller, A. M., and Rose-John, S. (1998) Blood, 92, 3495–3504.PubMedGoogle Scholar
  4. 4.
    Tupitsyn, N. N. (2001) Sovrem. Onkol., 3, 29–31.Google Scholar
  5. 5.
    Klein, B. (1998) Curr. Opin. Hematol., 5, 186–191.PubMedCrossRefGoogle Scholar
  6. 6.
    Stahl, N., Boulton, T. G., Farruggella, T., Ip, N. Y., Davis, S., Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Barbieri, G., and Pellegrin, S. (1994) Science, 263, 92–95.PubMedCrossRefGoogle Scholar
  7. 7.
    Ishihara, K., and Hirano, T. (2002) Biochim. Biophys. Acta, 1592, 281–296.PubMedCrossRefGoogle Scholar
  8. 8.
    Murakami, M., Narazaki, M., Hibi, M., Yawata, H., Yasukawa, K., Hamaguchi, M., Taga, T., and Kishimoto, T. (1991) Proc. Natl. Acad. Sci. USA, 88, 11349–11353.PubMedCrossRefGoogle Scholar
  9. 9.
    Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E., Jr., and Yancopoulos, G. D. (1995) Science, 267, 1349–1353.PubMedCrossRefGoogle Scholar
  10. 10.
    Fasnacht, N., and Muller, W. (2008) Semin. Cell. Dev. Biol., 19, 379–384.PubMedCrossRefGoogle Scholar
  11. 11.
    Hirano, T., Matsuda, T., and Nakajima, K. (1994) Stem Cells, 12, 262–277.PubMedCrossRefGoogle Scholar
  12. 12.
    Yamauchi-Takihara, K. (2008) Future Cardiol., 4, 427–437.PubMedCrossRefGoogle Scholar
  13. 13.
    Boulanger, M. J., Bankovich, A. J., Kortemme, T., Baker, D., and Garcia, K. C. (2003) Mol. Cell, 12, 577–589.PubMedCrossRefGoogle Scholar
  14. 14.
    Timmermann, A., Pflanz, S., Grotzinger, J., Kuster, A., Kurth, I., Pitard, V., Heinrich, P. C., and Muller-Newen, G. (2000) FEBS Lett., 468, 120–124.PubMedCrossRefGoogle Scholar
  15. 15.
    Bravo, J., and Heath, J. K. (2000) EMBO J., 19, 2399–2411.PubMedCrossRefGoogle Scholar
  16. 16.
    Steinberg, G. R., Watt, M. J., Ernst, M., Birnbaum, M. J., Kemp, B. E., and Jorgensen, S. B. (2009) Diabetes, 58, 829–839.PubMedCrossRefGoogle Scholar
  17. 17.
    Jung, I. D., Noh, K. T., Lee, C. M., Chun, S. H., Jeong, S. K., Park, J. W., Park, W. S., Kim, H. W., Yun, C. H., Shin, Y. K., and Park, Y. M. (2010) Biochem. Biophys. Res. Commun., 394, 272–278.PubMedCrossRefGoogle Scholar
  18. 18.
    Andratsch, M., Mair, N., Constantin, C. E., Scherbakov, N., Benetti, C., Quarta, S., Vogl, C., Sailer, C. A., Uceyler, N., Brockhaus, J., Martini, R., Sommer, C., Zeilhofer, H. U., Muller, W., Kuner, R., Davis, J. B., Rose-John, S., and Kress, M. (2009) J. Neurosci., 29, 13473–13483.PubMedCrossRefGoogle Scholar
  19. 19.
    Bazan, J. F. (1990) Proc. Natl. Acad. Sci. USA, 87, 6934–6938.PubMedCrossRefGoogle Scholar
  20. 20.
    Cosman, D. (1993) Cytokine, 5, 95–106.PubMedCrossRefGoogle Scholar
  21. 21.
    Bravo, J., Staunton, D., Heath, J. K., and Jones, E. Y. (1998) EMBO J., 17, 1665–1674.PubMedCrossRefGoogle Scholar
  22. 22.
    Wang, X., Lupardus, P., Laporte, S. L., and Garcia, K. C. (2009) Annu. Rev. Immunol., 27, 29–60.PubMedCrossRefGoogle Scholar
  23. 23.
    Diamant, M., Rieneck, K., Mechti, N., Zhang, X. G., Svenson, M., Bendtzen, K., and Klein, B. (1997) FEBS Lett., 412, 379–384.PubMedCrossRefGoogle Scholar
  24. 24.
    Narazaki, M., Yasukawa, K., Saito, T., Ohsugi, Y., Fukui, H., Koishihara, Y., Yancopoulos, G. D., Taga, T., and Kishimoto, T. (1993) Blood, 82, 1120–1126.PubMedGoogle Scholar
  25. 25.
    Mullberg, J., Dittrich, E., Graeve, L., Gerhartz, C., Yasukawa, K., Taga, T., Kishimoto, T., Heinrich, P. C., and Rose-John, S. (1993) FEBS Lett., 332, 174–178.PubMedCrossRefGoogle Scholar
  26. 26.
    Gaillard, J. P., Mani, J. C., Liautard, J., Klein, B., and Brochier, J. (1999) Eur. Cytokine Netw., 10, 43–48.PubMedGoogle Scholar
  27. 27.
    Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., and Kishimoto, T. (1990) Cell, 63, 1149–1157.PubMedCrossRefGoogle Scholar
  28. 28.
    Muller-Newen, G., Kuster, A., Hemmann, U., Keul, R., Horsten, U., Martens, A., Graeve, L., Wijdenes, J., and Heinrich, P. C. (1998) J. Immunol., 161, 6347–6355.PubMedGoogle Scholar
  29. 29.
    Liautard, J., Sun, R. X., Cotte, N., Gaillard, J. P., Mani, J. C., Klein, B., and Brochier, J. (1997) Cytokine, 9, 233–241.PubMedCrossRefGoogle Scholar
  30. 30.
    Chow, D. C., Brevnova, L., He, X. L., Martick, M. M., Bankovich, A., and Garcia, K. C. (2002) Biochim. Biophys. Acta, 1592, 225–235.PubMedCrossRefGoogle Scholar
  31. 31.
    Chow, D., He, X., Snow, A. L., Rose-John, S., and Garcia, K. C. (2001) Science, 291, 2150–2155.PubMedCrossRefGoogle Scholar
  32. 32.
    Hammacher, A., Richardson, R. T., Layton, J. E., Smith, D. K., Angus, L. J., Hilton, D. J., Nicola, N. A., Wijdenes, J., and Simpson, R. J. (1998) J. Biol. Chem., 273, 22701–22707.PubMedCrossRefGoogle Scholar
  33. 33.
    Pflanz, S., Kurth, I., Grotzinger, J., Heinrich, P. C., and Muller-Newen, G. (2000) J. Immunol., 165, 7042–7049.PubMedGoogle Scholar
  34. 34.
    Kurth, I., Horsten, U., Pflanz, S., Dahmen, H., Kuster, A., Grotzinger, J., Heinrich, P. C., and Muller-Newen, G. (1999) J. Immunol., 162, 1480–1487.PubMedGoogle Scholar
  35. 35.
    Skiniotis, G., Lupardus, P., Martick, M., Walz, T., and Garcia, K. C. (2008) Mol. Cell, 31, 737–748.PubMedCrossRefGoogle Scholar
  36. 36.
    Wells, J. A., and de Vos, A. M. (1996) Annu. Rev. Biochem., 65, 609–634.PubMedCrossRefGoogle Scholar
  37. 37.
    Livnah, O., Johnson, D. L., Stura, E. A., Farrell, F. X., Barbone, F. P., You, Y., Liu, K. D., Goldsmith, M. A., He, W., Krause, C. D., Pestka, S., Jolliffe, L. K., and Wilson, I. A. (1998) Nat. Struct. Biol., 5, 993–1004.PubMedCrossRefGoogle Scholar
  38. 38.
    Wijdenes, J., Heinrich, P. C., Muller-Newen, G., Roche, C., Gu, Z. J., Clement, C., and Klein, B. (1995) Eur. J. Immunol., 25, 3474–3481.PubMedCrossRefGoogle Scholar
  39. 39.
    Autissier, P., de Vos, J., Liautard, J., Tupitsyn, N., Jacquet, C., Chavdia, N., Klein, B., Brochier, J., and Gaillard, J. P. (1998) Int. Immunol., 10, 1881–1889.PubMedCrossRefGoogle Scholar
  40. 40.
    Auttisier, P., Liautard, J., Sun, R.-X., Cotte, N., Klein, B., Brochier, J., and Gaillard, J. P. (1997) in Leucocyte Typing VI (Kishimoto, T., Kikutani, H., von dem Borne, A. E. G. K., et al., eds.) Garlang Publishing, Inc., London, pp. 845–847.Google Scholar
  41. 41.
    Clement, C., and Wijdenes, J. (1997) in Leucocyte Typing VI (Kishimoto, T., Kikutani, H., von dem Borne, A. E. G. K., et al., eds.) Garlang Publishing, Inc., London, pp. 847–850.Google Scholar
  42. 42.
    Tupitsyn, N., Kadagidze, Z., Gaillard, J. P., Sholokhova, E., Andreeva, L., Liautard, J., Duperray, C., Klein, B., and Brochier, J. (1998) Clin. Lab. Haematol., 20, 345–352.PubMedCrossRefGoogle Scholar
  43. 43.
    Tupitsyn, N. N., Kadagidze, Z. G., and Sholokhova, E. N. (1999) Vestnik ONTs RAMN, 2, 11–18.Google Scholar
  44. 44.
    Harrison, P., Downs, T., Friese, P., Wolf, R., George, J. N., and Burstein, S. A. (1996) Br. J. Haematol., 95, 443–451.PubMedCrossRefGoogle Scholar
  45. 45.
    Chevalier, S., Fourcin, M., Robledo, O., Wijdenes, J., Pouplard-Barthelaix, A., and Gascan, H. (1996) J. Biol. Chem., 271, 14764–14772.PubMedCrossRefGoogle Scholar
  46. 46.
    Tupitsyn, N. N., and Brochier, J. (2000) Tissue Antigens, 4, 52.Google Scholar
  47. 47.
    Tupitsyn, N. N. (2001) Gematol. Transfuziol., 4, 9–14.Google Scholar
  48. 48.
    Brochier, J., Gaillard, J. P., and Klein, B. (1998) Curr. Trends Immunol., 1, 105–121.Google Scholar
  49. 49.
    Spiridonova, V. A., Lygina, A. S., Anohina, M. M., and Tupitsyn, N. N. (2007) Biochemistry (Moscow), 72, 424–429.CrossRefGoogle Scholar
  50. 50.
    Spiridonova, V. A., Bessonov, S. I., Tupitsyn, N. N., Shirokov, D. A., and Kopylov, A. M. (2007) Haematopoiesis Immunol., 4, 54–71.Google Scholar
  51. 51.
    Autissier, P., Liautard, J., Brochier, J., and Gaillard, J. P. (1997) Eur. J. Immunol., 27, 794–797.PubMedCrossRefGoogle Scholar
  52. 52.
    Muller-Newen, G., Kuster, A., Wijdenes, J., Schaper, F., and Heinrich, P. C. (2000) J. Biol. Chem., 275, 4579–4586.PubMedCrossRefGoogle Scholar
  53. 53.
    Tupitsyn, N. N., Andreeva, L. Yu., Vulfova, Yu. N., Morozova, L. F., Ovumyan, G. Sh., Chimishkyan, K. L., Brochier, J., Wijdenes, J., and Klein, B. (2000) Gematol. Transfuziol., 2, 3–12.Google Scholar
  54. 54.
    Schneider, H., Chaovapong, W., Matthews, D. J., Karkaria, C., Cass, R. T., Zhan, H., Boyle, M., Lorenzini, T., Elliott, S. G., and Giebel, L. B. (1997) Blood, 89, 473–482.PubMedGoogle Scholar
  55. 55.
    Hammacher, A., Wijdenes, J., Hilton, D. J., Nicola, N. A., Simpson, R. J., and Layton, J. E. (2000) Biochem. J., 345, 25–32.PubMedCrossRefGoogle Scholar
  56. 56.
    Timmermann, A., Kuster, A., Kurth, I., Heinrich, P. C., and Muller-Newen, G. (2002) Eur. J. Biochem., 269, 2716–2726.PubMedCrossRefGoogle Scholar
  57. 57.
    Matadeen, R., Hon, W. C., Heath, J. K., Jones, E. Y., and Fuller, S. (2007) Structure, 15, 441–448.PubMedCrossRefGoogle Scholar
  58. 58.
    Kurth, I., Horsten, U., Pflanz, S., Timmermann, A., Kuster, A., Dahmen, H., Tacken, I., Heinrich, P. C., and Muller-Newen, G. J. (2000) Immunology, 164, 273–282.Google Scholar
  59. 59.
    Grotzinger, J. (2002) Biochim. Biophys. Acta, 1592, 215–223.PubMedCrossRefGoogle Scholar
  60. 60.
    Qureshi, S. A., Kim, R. M., Konteatis, Z., Biazzo, D. E., Motamedi, H., Rodrigues, R., Boice, J. A., Calaycay, J. R., Bednarek, M. A., Griffin, P., Gao, Y. D., Chapman, K., and Mark, D. F. (1999) Proc. Natl. Acad. Sci. USA, 96, 12156–12161.PubMedCrossRefGoogle Scholar
  61. 61.
    Tenhumberg, S., Schuster, B., Zhu, L., Kovaleva, M., Scheller, J., Kallen, K. J., and Rose-John, S. (2006) Biochem. Biophys. Res. Commun., 346, 649–657.PubMedCrossRefGoogle Scholar
  62. 62.
    Van Snick, J. (1990) Annu. Rev. Immunol., 8, 253–278.PubMedCrossRefGoogle Scholar
  63. 63.
    Ichihara, M., Hara, T., Kim, H., Murate, T., and Miyajima, A. (1997) Blood, 90, 165–173.PubMedGoogle Scholar
  64. 64.
    Nepryakhina, O. K. (2005) Immunol. Gemopoeza, 2, 154–185.Google Scholar
  65. 65.
    Tupitsyn, N. N. (1999) Sovrem. Onkol., 1, 4–8.Google Scholar
  66. 66.
    Shirokov, D., Kadyrova, E., Anokhina, M., Kondratieva, T., Gourtsevitch, V., and Tupitsyn, N. (2007) J. Med. Virol., 79, 270–277.PubMedCrossRefGoogle Scholar
  67. 67.
    Zhang, X. G., Gaillard, J. P., Robillard, N., Lu, Z. Y., Gu, Z. J., Jourdan, M., Boiron, J. M., Bataille, R., and Klein, B. (1994) Blood, 83, 3654–3663.PubMedGoogle Scholar
  68. 68.
    Zhang, X. G., Gu, J. J., Lu, Z. Y., Yasukawa, K., Yancopoulos, G. D., Turner, K., Shoyab, M., Taga, T., Kishimoto, T., and Bataille, R. (1994) J. Exp. Med., 179, 1337–1342.PubMedCrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  1. 1.Cancer Research CenterRussian Academy of Medical SciencesMoscowRussia

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