Biochemistry (Moscow)

, Volume 76, Issue 4, pp 394–406 | Cite as

Functional properties of extracellular domains of transducer receptor gp130

  • M. N. Kostjukova
  • N. N. TupitsynEmail author


Cytokine receptor molecules have been shown to have extracellular domains of complex structure and a multistep activation system. Glycoprotein gp130 is a typical transducer of cytokine signal; it functions by forming multicomponent receptor complexes and transferring signals of tens of cytokines from the IL-6 family. Structural organization and basic functioning principles of gp130 are well known, as well as related signal pathways, which function during normal differentiation and are involved in pathogenesis of many tumors. The role of gp130 in IL-6-dependent tumors is best studied. In this review, based on extensive accumulated data, we examine the functional significance of certain parts of gp130 extracellular domains. Potentials of a recently developed method for estimation of receptor activation at the level of epitope structure are discussed.

Key words

gp130 activation cytokine immunophenotyping monoclonal antibodies receptor structure IL-6 cytokine-binding homology region 



cytokine-binding homology region


cardiotrophin-like cytokine


ciliary neurotrophic factor


ciliary neurotrophic factor receptor




enzyme-linked immunosorbent assay


interleukin-6 from human herpes virus type 8 genome


immunoglobulin-like domain

IL-6, -11,-27

interleukin 6, 11, 27


interleukin-6 receptor


signal cascade with participation of Janus-kinases (JAK) and signal transducers and activators of transcription (STAT)


leukemia inhibitory factor

LIFR (gp190)

leukemia inhibitory factor receptor


monoclonal antibodies




oncostatin M


signal cascade with participation of phosphatidylinositol 3-kinase and protein kinase B (AKT)


signal cascade with participation of membrane-bound GTPase Ras and mitogen-activating kinases (MAP)

Rm IL-6

interleukin-6 from rhesus macaque adenovirus genome


suppressor of cytokine signaling proteins


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© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  1. 1.Cancer Research CenterRussian Academy of Medical SciencesMoscowRussia

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