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Biochemistry (Moscow)

, Volume 76, Issue 3, pp 309–319 | Cite as

Endogenous opioid peptides in regulation of innate immunity cell functions

  • S. V. GeinEmail author
  • T. A. Baeva
Review

Abstract

Endogenous opioid peptides comprise a group of bioregulatory factors involved in regulation of functional activity of various physiological systems of an organism. One of most important functions of endogenous opioids is their involvement in the interaction between cells of the nervous and immune systems. Summary data on the effects of opioid peptides on regulation of functions of innate immunity cells are presented.

Key words

opioid peptides opiate receptors immunoregulatory effects monocytes/macrophages neutrophils NK cells dendritic cells cAMP 

Abbreviations

AC

adenylate cyclase

ACTH

adrenocorticotropic hormone

AP1

protein activator-1

ASK1

apoptosis-regulating kinase

CaM

calmodulin

cAMP

cyclic adenosine monophosphate

CBP

CREB-binding protein

ConA

con-canavalin A

CREB

(cAMP-response element-binding) transcription factor

CRF

corticotropin releasing factor

ERK

kinases regulated by extracellular signals

GPCR

G-protein-coupled receptors

IFN γ

γ interferon

JNK

c-Jun N-terminal protein kinases

LPS

lipopolysaccharide

MAPK

mitogen-activated protein kinases

γ-MSH

melanocyte stimulating hormone γ

NF-κB

nuclear κB factor

NK

natural killers

N/OFQ

nociceptin/orphanin FQ

ORL-1

(opioid receptor-like-1) nociceptin receptor

PKA

protein kinase A

PMA

phorbol myristate acetate

POMC

proopiomelanocortin

TAK1

TGF-β-regulated kinase

TGF β

transforming growth factor β

TNF-α

tumor necrosis factor α

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© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  1. 1.Institute of Ecology and Genetics of MicroorganismsUral Branch of the Russian Academy of SciencesPermRussia
  2. 2.Perm State UniversityPermRussia

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