Biochemistry (Moscow)

, Volume 76, Issue 3, pp 283–294 | Cite as

Eukaryotic type translation initiation factor 2: Structure–functional aspects

  • E. A. StolboushkinaEmail author
  • M. B. Garber


Translation initiation factor 2 (IF2) is one of key components of the translation initiation system in living cells. In bacteria IF2 is a multidomain monomeric protein, while in eukaryotic and archaean cells e/aIF2 is heterotrimer (αβγ). Data, including our own, on eukaryotic type translation initiation factor 2 (e/aIF2) structure and functioning are presented. There are also new data on initiation factors eIF5 and eIF2B that directly interact with eIF2 and control its participation in nucleotide exchange.

Key words

translation initiation e/aIF2 heterotrimer initiator methionyl-tRNA (Met-tRNAiMet-tRNAi·e/aIF2·GTP triple complex 



amino acid residue


C-terminal domain




hepatitis C virus


translation initiation factor


multifactor complex


N-terminal domain


inorganic phosphate


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  1. 1.
    Tahara, M., Ohsawa, A., Saito, S., and Kimura, M. (2004) Biochemistry (Tokyo), 135, 479–485.Google Scholar
  2. 2.
    Cho, S., and Hoffman, D. W. (2002) Biochemistry, 41, 5730–5742.PubMedGoogle Scholar
  3. 3.
    Dhaliwal, S., and Hoffman, D. W. (2003) J. Mol. Biol., 334, 187–195.PubMedGoogle Scholar
  4. 4.
    Gutierrez, P., Osborne, M. J., Siddiqui, N., Trempe, J. F., Arrowsmith, C., and Gehring, K. (2004) Protein Sci., 13, 659–667.PubMedGoogle Scholar
  5. 5.
    Ito, T., Marintchev, A., and Wagner, G. (2004) Structure, 12, 1693–1704.PubMedGoogle Scholar
  6. 6.
    Nikonov, O., Stolboushkina, E., Nikulin, A., Hasenohrl, D., Blasi, U., Manstein, D. J., Fedorov, R., Garber, M., and Nikonov, S. (2007) J. Mol. Biol., 373, 328–336.PubMedGoogle Scholar
  7. 7.
    Nonato, M. C., Widom, J., and Clardy, J. (2002) J. Biol. Chem., 277, 17057–17061.PubMedGoogle Scholar
  8. 8.
    Roll-Mecak, A., Alone, P., Cao, C., Dever, T. E., and Burley, S. K. (2004) J. Biol. Chem., 279, 10634–10642.PubMedGoogle Scholar
  9. 9.
    Schmitt, E., Blanquet, S., and Mechulam, Y. (2002) EMBO J., 21, 1821–1832.PubMedGoogle Scholar
  10. 10.
    Yatime, L., Schmitt, E., Blanquet, S., and Mechulam, Y. (2005) Biochemistry, 44, 8749–8756.PubMedGoogle Scholar
  11. 11.
    Sokabe, M., Yao, M., Sakai, N., Toya, S., and Tanaka, I. (2006) Proc. Natl. Acad. Sci. USA, 103, 13016–13021.PubMedGoogle Scholar
  12. 12.
    Yatime, L., Mechulam, Y., Blanquet, S., and Schmitt, E. (2006) Structure, 14, 119–128.PubMedGoogle Scholar
  13. 13.
    Yatime, L., Mechulam, Y., Blanquet, S., and Schmitt, E. (2007) Proc. Natl. Acad. Sci. USA, 104, 18445–18450.PubMedGoogle Scholar
  14. 14.
    Stolboushkina, E., Nikonov, S., Nikulin, A., Blasi, U., Manstein, D. J., Fedorov, R., Garber, M., and Nikonov, O. (2008) J. Mol. Biol., 382, 680–691.PubMedGoogle Scholar
  15. 15.
    Colthurst, D. R., and Proud, C. G. (1986) Biochim. Biophys. Acta, 868, 77–86.PubMedGoogle Scholar
  16. 16.
    Dever, T. E., Feng, L., Wek, R. C., Cigan, A. M., Donahue, T. F., and Hinnebusch, A. G. (1992) Cell, 68, 585–596.PubMedGoogle Scholar
  17. 17.
    Farrell, P. J., Balkow, K., Hunt, T., Jackson, R. J., and Trachsel, H. (1977) Cell, 11, 187–200.PubMedGoogle Scholar
  18. 18.
    Harding, H. P., Zhang, Y., and Ron, D. (1999) Nature, 397, 271–274.PubMedGoogle Scholar
  19. 19.
    Hinnebusch, A. G. (1996) in Translation Control of Gene Expression, Gold Spring Harbor, N. Y., pp. 199–244.Google Scholar
  20. 20.
    Shi, Y., Vattem, K. M., Sood, R., An, J., Liang, J., Stramm, L., and Wek, R. C. (1998) Mol. Cell. Biol., 18, 7499–7509.PubMedGoogle Scholar
  21. 21.
    Dar, A. C., Dever, T. E., and Sicheri, F. (2005) Cell, 122, 887–900.PubMedGoogle Scholar
  22. 22.
    Marissen, W. E., Guo, Y., Thomas, A. A., Matts, R. L., and Lloyd, R. E. (2000) J. Biol. Chem., 275, 9314–9323.PubMedGoogle Scholar
  23. 23.
    Satoh, S., Hijikata, M., Handa, H., and Shimotohno, K. (1999) Biochem. J., 342, 65–70.PubMedGoogle Scholar
  24. 24.
    Castilho-Valavicius, B., Thompson, G. M., and Donahue, T. F. (1992) Gene Expr., 1992, 297–309.Google Scholar
  25. 25.
    Donahue, T. F., Cigan, A. M., Pabich, E. K., and Valavicius, B. C. (1988) Cell, 54, 621–632.PubMedGoogle Scholar
  26. 26.
    Huang, H. K., Yoon, H., Hannig, E. M., and Donahue, T. F. (1997) Genes Dev., 11, 2396–2413.PubMedGoogle Scholar
  27. 27.
    Laurino, J. P., Thompson, G. M., Pacheco, E., and Castilho, B. A. (1999) Mol. Cell. Biol., 19, 173–181.PubMedGoogle Scholar
  28. 28.
    Asano, K., Krishnamoorthy, T., Phan, L., Pavitt, G. D., and Hinnebusch, A. G. (1999) EMBO J., 18, 1673–1688.PubMedGoogle Scholar
  29. 29.
    Das, S., Maiti, T., Das, K., and Maitra, U. (1997) J. Biol. Chem., 272, 31712–31718.PubMedGoogle Scholar
  30. 30.
    Erickson, F. L., Harding, L. D., Dorris, D. R., and Hannig, E. M. (1997) Mol. Gen. Genet., 253, 711–719.PubMedGoogle Scholar
  31. 31.
    Benne, R., Wong, C., Luedi, M., and Hershey, J. W. (1976) J. Biol. Chem., 251, 7675–7681.PubMedGoogle Scholar
  32. 32.
    Harbitz, I., and Hauge, J. G. (1976) Arch. Biochem. Biophys., 176, 766–778.PubMedGoogle Scholar
  33. 33.
    Levin, D. H., Kyner, D., and Acs, G. (1973) Proc. Natl. Acad. Sci. USA, 70, 41–45.PubMedGoogle Scholar
  34. 34.
    Safer, B., Adams, S. L., Anderson, W. F., and Merrick, W. C. (1975) J. Biol. Chem., 250, 9076–9082.PubMedGoogle Scholar
  35. 35.
    Schreier, M. H., and Staehelin, T. (1973) Nat. New Biol., 242, 35–38.PubMedGoogle Scholar
  36. 36.
    Shulman, R. G., Hilbers, C. W., and Miller, D. L. (1974) J. Mol. Biol., 90, 601–607.Google Scholar
  37. 37.
    Kapp, L. D., and Lorsch, J. R. (2004) J. Mol. Biol., 335, 923–936.PubMedGoogle Scholar
  38. 38.
    Von Pawel-Rammingen, U., Astrom, S., and Bystrom, A. S. (1992) Mol. Cell. Biol., 12, 1432–1442.Google Scholar
  39. 39.
    Farruggio, D., Chaudhuri, J., Maitra, U., and RajBhandary, U. L. (1996) Mol. Cell. Biol., 16, 4248–4256.PubMedGoogle Scholar
  40. 40.
    Yatime, L., Schmitt, E., Blanquet, S., and Mechulam, Y. (2004) J. Biol. Chem., 279, 15984–15993.PubMedGoogle Scholar
  41. 41.
    Drabkin, H. J., and RajBhandary, U. L. (1998) Mol. Cell. Biol., 18, 5140–1547.PubMedGoogle Scholar
  42. 42.
    Wagner, T., Gross, M., and Sigler, P. B. (1984) J. Biol. Chem., 259, 4706–4709.PubMedGoogle Scholar
  43. 43.
    Nissen, P., Kjeldgaard, M., Thirup, S., Polekhina, G., Reshetnikova, L., Clark, B. F., and Nyborg, J. (1995) Science, 270, 1464–1472.PubMedGoogle Scholar
  44. 44.
    Alone, P. V., and Dever, T. E. (2006) J. Biol. Chem., 281, 12636–12644.PubMedGoogle Scholar
  45. 45.
    Erickson, F. L., and Hannig, E. M. (1996) EMBO J., 15, 6311–6320.PubMedGoogle Scholar
  46. 46.
    Gaspar, N. J., Kinzy, T. G., Scherer, B. J., Humbelin, M., Hershey, J. W., and Merrick, W. C. (1994) J. Biol. Chem., 269, 3415–3422.PubMedGoogle Scholar
  47. 47.
    Nygerd, O., Westermann, P., and Hultin, T. (1980) FEBS Lett., 113, 125–128.Google Scholar
  48. 48.
    Westermann, P., Nygard, O., and Bielka, H. (1981) Nucleic Acid Res., 9, 2387–2396.PubMedGoogle Scholar
  49. 49.
    Das, A., Bagchi, M. K., Ghosh-Dastidar, P., and Gupta, N. K. (1982) J. Biol. Chem., 257, 1282–1288.PubMedGoogle Scholar
  50. 50.
    Mitsui, K., Datta, A., and Ochoa, S. (1981) Proc. Natl. Acad. Sci. USA, 78, 4128–4132.PubMedGoogle Scholar
  51. 51.
    Flynn, A., Oldfield, S., and Proud, C. G. (1993) Biochim. Biophys. Acta, 1174, 117–121.PubMedGoogle Scholar
  52. 52.
    Zardeneta, G., Kramer, G., and Hardesty, B. (1982) Proc. Natl. Acad. Sci. USA, 79, 3158–3161.PubMedGoogle Scholar
  53. 53.
    Nika, J., Rippel, S., and Hannig, E. M. (2001) J. Biol. Chem., 276, 1051–1056.PubMedGoogle Scholar
  54. 54.
    Pedulla, N., Palermo, R., Hasenohrl, D., Blasi, U., Cammarano, P., and Londei, P. (2005) Nucleic Acids Res., 33, 1804–1812.PubMedGoogle Scholar
  55. 55.
    Westermann, P., Heumann, W., Bommer, U. A., Bielka, H., Nygard, O., and Hultin, T. (1979) FEBS Lett., 97, 101–104.PubMedGoogle Scholar
  56. 56.
    Bommer, U. A., Stahl, J., Henske, A., Lutsch, G., and Bielka, H. (1988) FEBS Lett., 233, 114–118.PubMedGoogle Scholar
  57. 57.
    Lutsch, G., Noll, F., Theise, H., Enzmann, G., and Bielka, H. (1979) Mol. Gen. Genet., 176, 281–291.PubMedGoogle Scholar
  58. 58.
    Lutsch, G., Bielka, H., Enzmann, G., and Noll, F. (1983) Biomed. Biochim. Acta, 42, 705–723.PubMedGoogle Scholar
  59. 59.
    Lutsch, G., Stahl, J., Kargel, H. J., Noll, F., and Bielka, H. (1990) Eur. J. Cell. Biol., 51, 140–150.PubMedGoogle Scholar
  60. 60.
    Asano, K., Clayton, J., Shalev, A., and Hinnebusch, A. G. (2000) Genes Dev., 14, 2534–2546.PubMedGoogle Scholar
  61. 61.
    Olsen, D. S., Savner, E. M., Mathew, A., Zhang, F., Krishnamoorthy, T., Phan, L., and Hinnebusch, A. G. (2003) EMBO J., 22, 193–204.PubMedGoogle Scholar
  62. 62.
    Valasek, L., Nielsen, K. H., and Hinnebusch, A. G. (2002) EMBO J., 21, 5886–5898.PubMedGoogle Scholar
  63. 63.
    Alone, P. V., Cao, C., and Dever, T. E. (2008) Mol. Cell. Biol., 28, 6877–6888.PubMedGoogle Scholar
  64. 64.
    Cigan, A. M., Pabich, E. K., Feng, L., and Donahue, T. F. (1989) Proc. Natl. Acad. Sci. USA, 86, 2784–2788.PubMedGoogle Scholar
  65. 65.
    Dorris, D. R., Erickson, F. L., and Hannig, E. M. (1995) EMBO J., 14, 2239–2249.PubMedGoogle Scholar
  66. 66.
    Hashimoto, N. N., Carnevalli, L. S., and Castilho, B. A. (2002) Biochem. J., 367, 359–368.PubMedGoogle Scholar
  67. 67.
    Algire, M. A., Maag, D., and Lorsch, J. R. (2005) Mol. Cell, 20, 251–262.PubMedGoogle Scholar
  68. 68.
    Pestova, T. V., and Kolupaeva, V. G. (2002) Genes Dev., 16, 2906–2922.PubMedGoogle Scholar
  69. 69.
    Maag, D., Fekete, C. A., Gryczynski, Z., and Lorsch, J. R. (2005) Mol. Cell, 17, 265–275.PubMedGoogle Scholar
  70. 70.
    Passmore, L. A., Schmeing, T. M., Maag, D., Applefield, D. J., Acker, M. G., Algire, M. A., Lorsch, J. R., and Ramakrishnan, V. (2007) Mol. Cell, 26, 41–50.PubMedGoogle Scholar
  71. 71.
    Cheung, Y. N., Maag, D., Mitchell, S. F., Fekete, C. A., Algire, M. A., Takacs, J. E., Shirokikh, N., Pestova, T., Lorsch, J. R., and Hinnebusch, A. G. (2007) Genes Dev., 21, 1217–1230.PubMedGoogle Scholar
  72. 72.
    Hasenohrl, D., Fabbretti, A., Londei, P., Gualerzi, C. O., and Blasi, U. (2009) RNA, 15, 2288–2298.PubMedGoogle Scholar
  73. 73.
    Thompson, G. M., Pacheco, E., Melo, E. O., and Castilho, B. A. (2000) J. Biochem., 347, 703–709.Google Scholar
  74. 74.
    Dholakia, J. N., and Wahba, A. J. (1989) J. Biol. Chem., 264, 546–550.PubMedGoogle Scholar
  75. 75.
    Dholakia, J. N., Francis, B. R., Haley, B. E., and Wahba, A. J. (1989) J. Biol. Chem., 264, 20638–20642.PubMedGoogle Scholar
  76. 76.
    Nika, J., Yang, W., Pavitt, G. D., Hinnebusch, A. G., and Hannig, E. M. (2000) J. Biol. Chem., 275, 26011–26017.PubMedGoogle Scholar
  77. 77.
    Rowlands, A. G., Panniers, R., and Henshaw, E. C. (1988) J. Biol. Chem., 263, 5526–5533.PubMedGoogle Scholar
  78. 78.
    Salimans, M., Goumans, H., Amesz, H., Benne, R., and Voorma, H. O. (1984) Eur. J. Biochem., 145, 91–98.PubMedGoogle Scholar
  79. 79.
    Gomez, E., Mohammad, S. S., and Pavitt, G. D. (2002) EMBO J., 21, 5292–5301.PubMedGoogle Scholar
  80. 80.
    Pavitt, G. D., Ramaiah, K. V., Kimball, S. R., and Hinnebusch, A. G. (1998) Genes Dev., 12, 514–526.PubMedGoogle Scholar
  81. 81.
    Singh, C. R., Lee, B., Udagawa, T., Mohammad-Qureshi, S. S., Yamamoto, Y., Pavitt, G. D., and Asano, K. (2006) EMBO J., 25, 4537–4546.PubMedGoogle Scholar
  82. 82.
    Dev, K., Santangelo, T. J., Rothenburg, S., Neculai, D., Dey, M., Sicheri, F., Dever, T. E., Reeve, J. N., and Hinnebusch, A. G. (2009) J. Mol. Biol., 392, 701–722.PubMedGoogle Scholar
  83. 83.
    Colthurst, D. R., Campbell, D. G., and Proud, C. G. (1987) Eur. J. Biochem., 166, 357–363.PubMedGoogle Scholar
  84. 84.
    Boyce, M., Bryant, K. F., Jousse, C., Long, K., Harding, H. P., Scheuner, D., Kaufman, R. J., Ma, D., Coen, D. M., Ron, D., and Yuan, J. (2005) Science, 307, 935–939.PubMedGoogle Scholar
  85. 85.
    Jousse, C., Oyadomari, S., Novoa, I., Lu, P., Zhang, Y., Harding, H. P., and Ron, D. (2003) J. Cell Biol., 163, 767–775.PubMedGoogle Scholar
  86. 86.
    Amesz, H., Goumans, H., Haubrich-Morree, T., Voorma, H. O., and Benne, R. (1979) Eur. J. Biochem., 98, 513–520.PubMedGoogle Scholar
  87. 87.
    Cherbas, L., and London, I. M. (1976) Proc. Natl. Acad. Sci. USA, 73, 3506–3510.PubMedGoogle Scholar
  88. 88.
    Kimball, S. R., Heinzinger, N. K., Horetsky, R. L., and Jefferson, L. S. (1998) J. Biol. Chem., 273, 3039–3044.PubMedGoogle Scholar
  89. 89.
    Krishnamoorthy, T., Pavitt, G. D., Zhang, F., Dever, T. E., and Hinnebusch, A. G. (2001) Mol. Cell. Biol., 21, 5018–5030.PubMedGoogle Scholar
  90. 90.
    Safer, B. (1983) Cell, 33, 7–8.PubMedGoogle Scholar
  91. 91.
    Jennings, M. D., and Pavitt, G. D. (2010) Nature, 465, 378–381.PubMedGoogle Scholar
  92. 92.
    Robert, F., Kapp, L. D., Khan, S. N., Acker, M. G., Kolitz, S., Kazemi, S., Kaufman, R. J., Merrick, W. C., Koromilas, A. E., Lorsch, J. R., and Pelletier, J. (2006) Mol. Biol. Cell., 17, 4632–4644.PubMedGoogle Scholar
  93. 93.
    Terenin, I. M., Dmitriev, S. E., Andreev, D. E., and Shatsky, I. N. (2008) Nat. Struct. Mol. Biol., 15, 836–841.PubMedGoogle Scholar
  94. 94.
    Costa-Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, C., Sossin, W., Kaufman, R., Pelletier, J., Rosenblum, K., Krnjevic, K., Lacaille, J. C., Nader, K., and Sonenberg, N. (2007) Cell, 129, 195–206.PubMedGoogle Scholar
  95. 95.
    Sonenberg, N. (2008) Translation Control of Learning and Memory. Abstract book of the HHMI Meeting of International Research Scholars, Lisbon, Portugal, 19–22 June, p. 44.Google Scholar
  96. 96.
    Jeffrey, I. W., Bushell, M., Tilleray, V. J., Morley, S., and Clemens, M. J. (2002) Cancer Res., 62, 2272–2280.PubMedGoogle Scholar
  97. 97.
    Horton, L. E., Bushell, M., Barth-Baus, D., Tilleray, V. J., Clemens, M. J., and Hensold, J. O. (2002) Oncogene, 21, 5325–5334.PubMedGoogle Scholar
  98. 98.
    Engelberg-Kulka, H., Sat, B., Reches, M., Amitai, S., and Hazan, R. (2004) Trends Microbiol., 12, 66–71.PubMedGoogle Scholar
  99. 99.
    Sat, B., Hazan, R., Fisher, T., Khaner, H., Glaser, G., and Engelberg-Kulka, H. (2001) J. Bacteriol., 183, 2041–2045.PubMedGoogle Scholar
  100. 100.
    Clark, S. J., Ashford, A. J., Price, N. T., and Proud, C. G. (1989) Biochim. Biophys. Acta, 1010, 377–380.PubMedGoogle Scholar
  101. 101.
    Welsh, G. I., Price, N. T., Bladergroen, B. A., Bloomberg, G., and Proud, C. G. (1994) Biochem. Biophys. Res. Commun., 201, 1279–1288.PubMedGoogle Scholar
  102. 102.
    Gonzatti, M. I., and Traugh, J. A. (1988) Biochem. Biophys. Res. Commun., 157, 134–139.PubMedGoogle Scholar
  103. 103.
    Luis, A. M., Izquierdo, J. M., Ostronoff, L. K., Salinas, M., Santaren, J. F., and Cuezva, J. M. (1993) J. Biol. Chem., 268, 1868–1875.PubMedGoogle Scholar
  104. 104.
    Martin, M. E., Alcazar, A., and Salinas, M. (1990) Int. J. Dev. Neurosci., 8, 47–54.PubMedGoogle Scholar
  105. 105.
    Barrieux, A., and Rosenfeld, M. G. (1977) J. Biol. Chem., 252, 392–398.PubMedGoogle Scholar
  106. 106.
    Del Angel, R. M., Papavassiliou, A. G., Fernandez-Tomas, C., Silverstein, S. J., and Racaniello, V. R. (1989) Proc. Natl. Acad. Sci. USA, 86, 8299–8303.PubMedGoogle Scholar
  107. 107.
    Itamar, D., Gonsky, R., Lebendiker, M., and Kaempfer, R. (1984) Eur. J. Biochem., 145, 373–379.PubMedGoogle Scholar
  108. 108.
    Kaempfer, R., Hollender, R., Abrams, W., and Israeli, R. (1978) Proc. Natl. Acad. Sci. USA, 75, 209–213.PubMedGoogle Scholar
  109. 109.
    Kaempfer, R., Rosen, H., and Israeli, R. (1978) Proc. Natl. Acad. Sci. USA, 75, 650–654.PubMedGoogle Scholar
  110. 110.
    Kaempfer, R., van Emmelo, J., and Fiers, W. (1981) Proc. Natl. Acad. Sci. USA, 78, 1542–1546.PubMedGoogle Scholar
  111. 111.
    Perez-Bercoff, R., and Kaempfer, R. (1982) J. Virol., 41, 30–41.PubMedGoogle Scholar
  112. 112.
    Scheper, G. C., Thomas, A. A., and Voorma, H. O. (1991) Biochim. Biophys. Acta, 1089, 220–226.PubMedGoogle Scholar
  113. 113.
    Flynn, A., Shatsky, I. N., Proud, C. G., and Kaminski, A. (1994) Biochim. Biophys. Acta, 1219, 293–301.PubMedGoogle Scholar
  114. 114.
    Rosen, H., and Kaempfer, R. (1979) Biochem. Biophys. Res. Commun., 91, 449–455.PubMedGoogle Scholar
  115. 115.
    Harary, R., and Kaempfer, R. (1990) Biochim. Biophys. Acta, 1050, 129–133.PubMedGoogle Scholar
  116. 116.
    Gonsky, R., Lebendiker, M. A., Harary, R., Banai, Y., and Kaempfer, R. (1990) J. Biol. Chem., 265, 9083–9089.PubMedGoogle Scholar
  117. 117.
    Gonsky, R., Itamar, D., Harary, R., and Kaempfer, R. (1992) Biochimie, 74, 427–434.PubMedGoogle Scholar
  118. 118.
    Van Heugten, H. A., Kasperaitis, M. A., Thomas, A. A., and Voorma, H. O. (1991) J. Biol. Chem., 266, 7279–7284.PubMedGoogle Scholar
  119. 119.
    Van Heugten, H. A., Thomas, A. A., and Voorma, H. O. (1992) Biochimie, 74, 463–475.PubMedGoogle Scholar
  120. 120.
    Di Segni, G., Rosen, H., and Kaempfer, R. (1979) Biochemistry, 18, 2847–2854.PubMedGoogle Scholar
  121. 121.
    Rosen, H., Knoller, S., and Kaempfer, R. (1981) Biochemistry, 20, 3011–3020.PubMedGoogle Scholar
  122. 122.
    Rosen, H., Di Segni, G., and Kaempfer, R. (1982) J. Biol. Chem., 257, 946–952.PubMedGoogle Scholar
  123. 123.
    Dmitriev, C. E., Terenin, I. M., Rubtsova, M. P., and Shatsky, I. N. (2003) Mol. Biol. (Moscow), 37, 494–503.Google Scholar
  124. 124.
    Seal, S. N., Schmidt, A., and Marcus, A. (1989) J. Biol. Chem., 264, 7363–7368.PubMedGoogle Scholar
  125. 125.
    Hasenohrl, D., Lombo, T., Kaberdin, V., Londei, P., and Blasi, U. (2008) Proc. Natl. Acad. Sci. USA, 105, 2146–2150.PubMedGoogle Scholar
  126. 126.
    Jia, M. Z., Horita, S., Nagata, K., and Tanokura, M. (2010) J. Mol. Biol., 398, 774–785.PubMedGoogle Scholar

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© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  1. 1.Institute of Protein ResearchRussian Academy of SciencesPushchino, Moscow RegionRussia

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