Biochemistry (Moscow)

, Volume 76, Issue 1, pp 61–68 | Cite as

DNA polymerase ι of mammals as a participant in translesion synthesis of DNA

  • L. V. GeningEmail author


This review describes the properties of some specialized DNA polymerases participating in translesion synthesis of DNA. Special attention is given to these properties in vivo. DNA polymerase iota (Polι) of mammals has very unusual features and is extremely error-prone. Based on available data, a hypothesis is proposed explaining how mammalian cells can explore the unusual features of DNA Polι to bypass DNA damages and to simultaneously prevent its mutagenic potential.

Key words

DNA translesion synthesis error-prone DNA polymerase DNA polymerase ι 



apurinic/apyrimidinic endonuclease 1


cisplatinum adduct


cis-syn-thymine-thymine dimer


hypoxia-inducible factor 1


hypoxia response element


poly(ADP-ribose) polymerase 1


proliferating cell nuclear antigen


PCNA interaction protein box


polynucleotide kinase

Polι, Polη, Polζ, Polκ, RevI, Polβ, Polλ, Polα, Polδ, and Polɛ

DNA polymerases ι, η, ζ, κ, RevI, β, λ, α, δ, and ɛ, respectively


replication factor C


replication protein A


xeroderma pigmentosum variant V


X-ray repair complementing defective repair in Chinese hamster cells 1


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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  1. 1.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia

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