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Biochemistry (Moscow)

, Volume 76, Issue 1, pp 61–68 | Cite as

DNA polymerase ι of mammals as a participant in translesion synthesis of DNA

  • L. V. GeningEmail author
Review

Abstract

This review describes the properties of some specialized DNA polymerases participating in translesion synthesis of DNA. Special attention is given to these properties in vivo. DNA polymerase iota (Polι) of mammals has very unusual features and is extremely error-prone. Based on available data, a hypothesis is proposed explaining how mammalian cells can explore the unusual features of DNA Polι to bypass DNA damages and to simultaneously prevent its mutagenic potential.

Key words

DNA translesion synthesis error-prone DNA polymerase DNA polymerase ι 

Abbreviations

APE1

apurinic/apyrimidinic endonuclease 1

cisPt-GG

cisplatinum adduct

csTT

cis-syn-thymine-thymine dimer

HIF1

hypoxia-inducible factor 1

HRE

hypoxia response element

PARP1

poly(ADP-ribose) polymerase 1

PCNA

proliferating cell nuclear antigen

PIP1(PIP2)

PCNA interaction protein box

PNK

polynucleotide kinase

Polι, Polη, Polζ, Polκ, RevI, Polβ, Polλ, Polα, Polδ, and Polɛ

DNA polymerases ι, η, ζ, κ, RevI, β, λ, α, δ, and ɛ, respectively

RFC

replication factor C

RPA

replication protein A

XP-V

xeroderma pigmentosum variant V

XRCC1

X-ray repair complementing defective repair in Chinese hamster cells 1

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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  1. 1.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia

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