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Biochemistry (Moscow)

, Volume 75, Issue 11, pp 1383–1387 | Cite as

Effect of Plastoquinone Derivative 10-(6′-Plastoquinonyl)decyltriphenylphosphonium (SkQ1) on Contents of Steroid Hormones and NO Level in Rats

  • V. A. Chistyakov
  • V. A. Serezhenkov
  • A. A. Alexandrova
  • N. P. Milyutina
  • V. N. Prokof’ev
  • E. V. Mashkina
  • L. V. Gutnikova
  • S. V. Dem’yanenko
Article

Abstract

Introduction of the plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) into male Wistar rats once a day for two weeks in doses of 25 and 250 nmol/kg led to elevation of 17ß-estradiol level in blood serum by 33 and 41%, respectively. At the same time, nitrate and nitrite contents in the rat blood serum increased by 49 and 34%, respectively. ESR spectroscopy with diethyldithiocarbamate-iron complex as a spin trap showed more than twofold increase in NO production in lungs, but not in blood, liver, and intestines, following the SkQ1 daily introduction at a dose of 25 nmol/kg.

Key words

SkQ1 penetrating cations steroid hormones estradiol nitrate nitrite nitric oxide 

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • V. A. Chistyakov
    • 1
  • V. A. Serezhenkov
    • 2
  • A. A. Alexandrova
    • 1
  • N. P. Milyutina
    • 1
  • V. N. Prokof’ev
    • 1
  • E. V. Mashkina
    • 1
  • L. V. Gutnikova
    • 1
  • S. V. Dem’yanenko
    • 1
  1. 1.Research Institute of BiologySouthern Federal UniversityRostov-na-DonuRussia
  2. 2.Semenov Institute of Chemical PhysicsRussian Academy of SciencesMoscowRussia

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