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Biochemistry (Moscow)

, Volume 75, Issue 9, pp 1069–1087 | Cite as

Role of 4-hydroxy-trans-2-nonenal in cell functions

  • E. E. DubininaEmail author
  • V. A. Dadali
Review

Abstract

The role of lipid peroxidation product 4-hydroxy-trans-2-nonenal (4-HNE) in functional activity of cells under normal and different pathological conditions is discussed. Different pathways of 4-HNE metabolism in tissues are analyzed, with particular focus on the role the glutathione system in this process. 4-HNE is implicated in regulation of cell growth, proliferation, differentiation, and apoptosis. 4-HNE and metabolic products of other antioxidants (carotenoids) resemble each other in chemical nature of the product and influence general pathways of signal transduction. Manifestation of 4-HNE toxicity under oxidative stress conditions is regarded as a link to many diseases whose pathogenesis is connected with modifications of proteins and nucleic acids.

Key words

4-hydroxy-trans-2-nonenal lipid peroxidation apoptosis glutathione system carotenoids oxidative stress 

Abbreviations

AD

Alzheimer’s disease

ALDH

NAD+-dependent aldehyde dehydrogenase

AO

antioxidant

GCL

glutamate-cysteine ligase (γ-glutamyl-L-cysteine synthetase)

GGTP

γ-glutamyl transpeptidase

GS

glutathione synthetase

4-HNE

4-hydroxy-trans-2-nonenal

IL

interleukin

LPO

lipid peroxidation

MDA

malonic dialdehyde

Nrf2

zinc-binding protein, an NF-E2 related factor 2

OS

oxidative stress

PI3K

phosphatidylinositol 3-kinase

pRb

retinoblastoma protein

PUFA

polyunsaturated fatty acid

ROS

reactive oxygen species

Shc

SHC-adaptor protein

TNF-α

tumor necrosis factor alpha

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Bekhterev St. Petersburg Psychoneurological Research InstituteSt. PetersburgRussia
  2. 2.Mechnikov St. Petersburg State Medical AcademySt. PetersburgRussia

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