Biochemistry (Moscow)

, Volume 75, Issue 7, pp 811–824 | Cite as

“Smart” liposomal nanocontainers in biology and medicine

  • Y. S. TarahovskyEmail author


The perspectives of using liposomes for delivery of drugs to desired parts of the human body have been intensively investigated for more than 30 years. During this time many inventions have been suggested and different kinds of liposomal devices developed, and a number of them have reached the stages of preclinical or clinical trials. The latest techniques can be used to develop biocompatible nano-sized liposomal containers having some abilities of artificial intellect, such as the presence of sensory and responsive units. However, only a few have been clinically approved. Further improvements in this area depend on our knowledge of the interactions of drugs with the lipid bilayer of liposomes. Further studies on liposomal transport through the human body, their targeting of cells requiring therapeutic treatment, and finally, the development of techniques for controlled drug delivery to desired acceptors on cell surfaces or in cytoplasm are still required.

Key words

liposomes intellectual nanocontainers drugs targeting nanomedicine 



cholesteryl hemisuccinate


dioleoyl phosphatidylethanolamine


dipalmitoyl phosphatidylcholine


distearoyl phosphatidylcholine


enhanced permeability and retention


folate receptor


hexadecyl phosphocholine


infrared light


oleic acid


phosphatidic acid










reticuloendothelial system


reduced folate carrier


ultraviolet light


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© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Institute of Theoretical and Experimental BiophysicsRussian Academy of SciencesPushchino, Moscow RegionRussia

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