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Biochemistry (Moscow)

, Volume 75, Issue 4, pp 505–512 | Cite as

Synthesis, characterization, and studies on DNA binding of the complex Fe(Sal2dienNO3·H2O)

  • Cheng-Yong ZhouEmail author
  • Yan-Bo Wu
  • Pin Yang
Article

Abstract

A new metal complex, Fe(Sal2dienNO3·H2O) (where Sal is salicylaldehyde and dien is diethylenetriamine), has been synthesized and characterized. The interactions between the Fe(III) complex and calf thymus DNA has been investigated using UV and fluorescence spectra, viscosity, thermal denaturation, and molecular modeling. The cleavage reaction on plasmid DNA has been monitored by agarose gel electrophoresis. The experimental results show that the mode of binding of the complex to DNA is classical intercalation and the complex can cleave pBR322 DNA.

Key words

DNA binding Fe(Sal2dienNO3·H2O) Fe(III) complex calf thymus DNA 

Abbreviations

CT DNA

calf thymus DNA

DFT

density functional theory

dien

diethylenetriamine

DMSO

dimethyl sulfoxide

EB

ethidium bromide

ESFF

extensive systematic force field

HRMS

high resolution mass spectrum

Sal

salicylaldehyde

TMS

tetramethylsilane

TS

transition states

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Department of ChemistryChangzhi UniversityShanxi ChangzhiPR China
  2. 2.Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education, Institute of Molecular ScienceShanxi UniversityTaiyuan, ShanxiPR China

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