Biochemistry (Moscow)

, Volume 75, Issue 3, pp 281–296 | Cite as

Oxidative stress in yeast

  • V. I. LushchakEmail author


The mechanisms of production and elimination of reactive oxygen species in the cells of the budding yeast Saccharomyces cerevisiae are analyzed. Coordinative role of special regulatory proteins including Yap1p, Msn2/4p, and Skn7p (Pos9p) in regulation of defense mechanisms in S. cerevisiae is described. A special section is devoted to two other well-studied species from the point of view of oxidative stress — Schizosaccharomyces pombe and Candida albicans. Some examples demonstrating the use of yeast for investigation of apoptosis, aging, and some human diseases are given in the conclusion part.

Key words

yeast Saccharomyces cerevisiae Schizosaccharomyces pombe Candida albicans oxidative stress response regulatory proteins 





cAMP-dependent protein kinase A




glucose-6-phosphate dehydrogenase


reactive oxygen species


superoxide dismutase


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© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Department of BiochemistryVassyl Stefanyk Precarpathian National UniversityIvano-FrankivskUkraine

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