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Biochemistry (Moscow)

, Volume 75, Issue 2, pp 145–150 | Cite as

New-generation Skulachev ions exhibiting nephroprotective and neuroprotective properties

  • E. Y. Plotnikov
  • D. N. Silachev
  • A. A. Chupyrkina
  • M. I. Danshina
  • S. S. Jankauskas
  • M. A. Morosanova
  • E. V. Stelmashook
  • A. K. Vasileva
  • E. S. Goryacheva
  • Y. A. Pirogov
  • N. K. IsaevEmail author
  • D. B. ZorovEmail author
Article

Abstract

A mitochondria-targeted chimeric compound consisting of a rhodamine derivative linked to a plastoquinone molecule (10-(6′-plastoquinonyl)decylrhodamine, SkQR1) was studied under conditions of acute brain or kidney damage. A protective effect of this compound was demonstrated in a model of focal brain ischemia, rat kidney ischemia/reperfusion, myoglobinuria (rhabdomyolysis, or crush syndrome), and pyelonephritis. We found that a single intraperitoneal injection of SkQR1 diminishes the size of the ischemic zone in the brain and improves performance of a test characterizing neurological deficit in ischemic animals. An analog of SkQR1 not containing plastoquinone (C12R19) was not neuroprotective. The data show that SkQR1 is a nephroprotectant and neuroprotectant, which can be due to the antioxidative action of this Skulachev cation.

Key words

Skulachev ions SkQ SkQR1 kidney oxidative stress mitochondria-targeted antioxidants mitochondria rhabdomyolysis pyelonephritis brain ischemia magnetic resonance tomography 

Abbreviations

AKI

acute kidney injury

DCF

2,7-dichlorodi-hydrofluorescein diacetate

MRI

magnetic resonance imaging

ROS

reactive oxygen species

SkQ

cationic derivatives of plastoquinone

SkQR1

10-(6′-plastoquinonyl)decylrhodamine 19

TTC

2,3,5-triphenyl tetrazolium chloride

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Supplementary material

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • E. Y. Plotnikov
    • 1
    • 2
  • D. N. Silachev
    • 1
    • 2
  • A. A. Chupyrkina
    • 1
    • 2
  • M. I. Danshina
    • 2
  • S. S. Jankauskas
    • 2
  • M. A. Morosanova
    • 2
    • 3
  • E. V. Stelmashook
    • 2
    • 4
  • A. K. Vasileva
    • 1
    • 2
  • E. S. Goryacheva
    • 2
    • 3
  • Y. A. Pirogov
    • 5
  • N. K. Isaev
    • 1
    • 2
    • 4
    Email author
  • D. B. Zorov
    • 1
    • 2
    Email author
  1. 1.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Mitoengineering Research InstituteLomonosov Moscow State UniversityMoscowRussia
  3. 3.Faculty of Bioengineering and BioinformaticsLomonosov Moscow State UniversityMoscowRussia
  4. 4.Department of Brain Research, Neurology Research CenterRussian Academy of Medical SciencesMoscowRussia
  5. 5.Training and Research Interfaculty Center of Magnetic Tomography and SpectroscopyLomonosov Moscow State UniversityMoscowRussia

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