Biochemistry (Moscow)

, Volume 74, Issue 13, pp 1505–1534 | Cite as

Molecular diversity of spider venom

Review

Abstract

Spider venom, a factor that has played a decisive role in the evolution of one of the most successful groups of living organisms, is reviewed. Unique molecular diversity of venom components including substances of variable structure (from simple low molecular weight compounds to large multidomain proteins) with different functions is considered. Special attention is given to the structure, properties, and biosynthesis of toxins of polypeptide nature.

Key words

spider venom toxin neurotoxin cytolytic peptide acylpolyamine latrotoxin toxic enzymes protein structure and function biosynthesis 

Abbreviations

a.a.

amino acid residue

AMP

antimicrobial peptide

AP

acylpolyamine

CP

cytolytic peptide

CSαβ

cysteine-stabilized α-helix-β-sheet motif

DDH

disulfide-directed β-hairpin motif

ER

endoplasmic reticulum

ESM

extra structural motif

ICK

inhibitor cystine knot motif

LD50

median lethal dose

Mm

molecular mass

NMR

nuclear magnetic resonance

PSM

principal structural motif

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Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  1. 1.Shemyakin-Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia

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