Biochemistry (Moscow)

, Volume 74, Issue 10, pp 1150–1154 | Cite as

High-resolution atomic force microscopy of DNA

  • D. V. KlinovEmail author
  • T. V. Neretina
  • V. V. Prokhorov
  • T. V. Dobrynina
  • K. G. Aldarov
  • V. V. Demin


A method using high resolution atomic force microscopy for imaging DNA has been elaborated. Using super-sharp probes and modified graphite as support for molecule adsorption, DNA molecule images were obtained whose resolution made possible the observation of their fine structure with repeated helical motifs. The method can be used to visualize individual spread molecules of single-stranded DNA.

Key words

AFM high resolution DNA scanning probes HOPG 



atomic-force microscopy


highly oriented pyrolitic graphite


single-stranded DNA


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Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  • D. V. Klinov
    • 1
    Email author
  • T. V. Neretina
    • 1
  • V. V. Prokhorov
    • 1
  • T. V. Dobrynina
    • 1
  • K. G. Aldarov
    • 1
  • V. V. Demin
    • 1
  1. 1.Shemyakin-Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia

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