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Biochemistry (Moscow)

, Volume 74, Issue 10, pp 1070–1079 | Cite as

Dendrimers in gene transfection

  • D. G. ShcharbinEmail author
  • B. Klajnert
  • M. BryszewskaEmail author
Review

Abstract

Dendrimers are a new class of nanocomposite materials. They are branching polymers whose structure is formed by monomeric subunit branches diverging to all sides from a central nucleus. The type of nucleus, attached monomers, and functional groups can be chosen during synthesis, which produces dendrimers of definite size, shape, density, polarity, branch mobility, and solubility. This review deals with problems of dendrimer molecular structures and capability of in vitro, in vivo, ex vivo, and in situ transfection of genetic material. Advantages and shortcomings of different types of dendrimers in this respect are discussed.

Key words

dendrimer complex transfection gene DNA RNA 

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Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  1. 1.Institute of Biophysics and Cell EngineeringNational Academy of Sciences of BelarusMinskBelarus
  2. 2.Department of General BiophysicsUniversity of LodzLodzPoland

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