Biochemistry (Moscow)

, Volume 73, Issue 13, pp 1511–1518 | Cite as

D-Amino acid oxidase: Physiological role and applications

  • S. V. Khoronenkova
  • V. I. TishkovEmail author


D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids. The most interesting and important data for regulation of the nervous system, hormone secretion, and other processes by D-amino acids as well as development of different diseases under changed DAAO activity are presented. The mechanism of regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects. Use of DAAO for diagnostic and therapeutic purposes is also considered.

Key words

D-amino acid oxidase physiological role practical application 



7-aminocephalosporanic acid


D-amino acid oxidase






D-amino acid oxidases from porcine kidney, Trigonopsis variabilis, and Rhodotorula gracilis, respectively.


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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Chemistry FacultyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Innovations and High Technologies MSU Ltd.MoscowRussia
  3. 3.Bach Institute of BiochemistryRussian Academy of SciencesMoscowRussia

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