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Biochemistry (Moscow)

, Volume 73, Issue 13, pp 1493–1510 | Cite as

Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes

  • E. V. Kalinina
  • N. N. Chernov
  • A. N. SaprinEmail author
Review

Abstract

Among the key antioxidant enzymes, thioredoxin and glutaredoxin systems play an important role in cell defense against oxidative stress and maintenance of redox homeostasis owing to the regulation of thiol—disulfide exchange. The thioredoxin isoforms Trx1 (cytoplasmic form) and Trx2 (mitochondrial form) can reduce inter- and intramolecular disulfide bonds in proteins, in particular, in oxidized peroxiredoxins, which disrupt organic hydroperoxides, H2O2, and peroxynitrite. NADPH-dependent thioredoxin reductase, which reduces a broad range of substrates including oxidized form of thioredoxin, can also directly reduce lipid hydroperoxides, H2O2, and dehydroascorbic and lipoic acids. Glutaredoxin, whose major isoforms in mammals are Grx1, Grx2, and Grx5, as well as thioredoxin, catalyzes S-glutathionylation and deglutathionylation of proteins to protect SH-groups from oxidation and restore functionally active thiols. However, in contrast to thioredoxin, glutaredoxin reduces GSH-mixed disulfides and catalyzes the reaction not only via a dithiol mechanism but also via monothiol reduction. In addition to the role in cellular antioxidant defense, all of the reviewed redox proteins (thioredoxin, thioredoxin reductase, peroxiredoxin, and glutaredoxin) have a number of significant functions required for cell viability: they regulate transcription factor activities, play the role of growth factors, serve as enzyme cofactors, take part in regulation of cell cycle, and are involved in antiapoptotic mechanisms.

Key words

oxidative stress thioredoxin thioredoxin reductase peroxiredoxin glutaredoxin redox-dependent processes 

Abbreviations

AP-1

activator protein 1

ARE

antioxidant-responsive element

ASK-1

apoptosis signal-regulating kinase 1

Cdc2

cyclin-dependent kinase 2

ERK

extracellular signal regulated kinase

Grx

glutaredoxin

GSH and GSSG

glutathione reduced and oxidized, respectively

GST P1-1

glutathione transferase P1-1

IκB

inhibitor of κB

iNOS

inducible NO-synthase

JNK

c-Jun-N-terminal kinase

MAPK

mitogen-activated protein kinase

MEK

MAPK/ERK kinase

Mn-SOD

Mn-dependent superoxide dismutase

NF-κB

nuclear factor κB

Nrf2

NF-E2-dependent factor 2

PDI

protein disulfide isomerase

PKC

protein kinase C

Prx

perox-iredoxin

ROS

reactive oxygen species

SAPK

stress-activated protein kinase

Sec

selenocysteine

SEK

SAPK/ERK kinase

Trx

thioredoxin

Trx1 and Trx2

cytoplasmic and mitochondrial Trx forms, respectively

TrxR

thioredoxin reductase

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • E. V. Kalinina
    • 1
    • 2
  • N. N. Chernov
    • 3
  • A. N. Saprin
    • 1
    Email author
  1. 1.Center for Theoretical Problems of Physico-Chemical PharmacologyRussian Academy of SciencesMoscowRussia
  2. 2.Institute of Cytochemistry and Molecular PharmacologyMoscowRussia
  3. 3.Peoples’ Friendship University of RussiaMoscowRussia

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