Biochemistry (Moscow)

, Volume 73, Issue 13, pp 1453–1466 | Cite as

Intermediate vimentin filaments and their role in intracellular organelle distribution

  • A. A. MininEmail author
  • M. V. Moldaver


Intermediate filaments (IF) represent one of three main cytoskeletal structures in most animal cells. The human IF protein family includes about 70 members divided into five main groups. The characteristic feature of IF is that in various cells and tissues they are formed by proteins of different groups. Structures of all IF proteins follow a unique scheme: a central α-helical part is flanked at the N and C ends by positively charged polypeptide chains devoid of a clear secondary structure. The central part is highly conserved for all proteins in all animals, whereas the N and C termini strongly differ both in size and amino acid composition. This review covers the broad spectrum of recent investigations of IF structure and diverse functions. Special attention is paid to the regulatory mechanisms of IF functions, mainly to phosphorylation by different protein kinases whose role is well studied. The review gives examples of hereditary diseases associated with mutations of some IF proteins, which point to an important physiological role of these cytoskeletal structures.

Key words

intermediate filaments vimentin keratins cytoskeleton 



actin-binding domain


oncogene 2 of B-cell lymphoma


bullous pemphigoid antigen 1


Ca-calmodulin-sensitive protein kinase


cell division cycle protein kinase


electron paramagnetic resonance


endoplasmic reticulum


glial filament acidic protein


glycogen synthase kinase


intermediate filaments


intermediate filament-associated proteins


lysosome-bound membrane protein


microtubule-binding domain


light, medium, and heavy neurofilament proteins


protein kinase activated by p21 protein


protein kinase A


protein kinase C


small-angle X-ray scattering


integral proteins of nuclear membrane


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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Institute of Protein ResearchRussian Academy of SciencesPushchino, Moscow RegionRussia
  2. 2.Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia

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