Biochemistry (Moscow)

, Volume 73, Issue 13, pp 1388–1404 | Cite as

Mechanisms of single-stranded DNA-binding protein functioning in cellular DNA metabolism

  • P. E. Pestryakov
  • O. I. LavrikEmail author


This review deals with analysis of mechanisms involved in coordination of DNA replication and repair by SSB proteins; characteristics of eukaryotic, prokaryotic, and archaeal SSB proteins are considered, which made it possible to distinguish general mechanisms specific for functioning of proteins from organisms of different life domains. Mechanisms of SSB protein interactions with DNA during metabolism of the latter are studied; structural organization of the SSB protein complexes with DNA, as well as structural and functional peculiarities of different SSB proteins are analyzed.

Key words

SSB proteins replication protein A protein-DNA complexes DNA replication DNA repair 



amino acid residues


double-stranded DNA


Escherichia coli SSB


Homo sapiens RPA


nucleotide excision repair



OB domain

oligosaccharide/oligonucleotide-binding domain


proliferating cell nuclear antigen


DNA polymerase α-primase complex


replication factor C


replication protein A


single-stranded DNA-binding protein


single-stranded DNA


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© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Institute of Chemical Biology and Fundamental MedicineSiberian Branch of the Russian Academy of SciencesNovosibirskRussia

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