Mechanisms of single-stranded DNA-binding protein functioning in cellular DNA metabolism
- First Online:
- 64 Downloads
This review deals with analysis of mechanisms involved in coordination of DNA replication and repair by SSB proteins; characteristics of eukaryotic, prokaryotic, and archaeal SSB proteins are considered, which made it possible to distinguish general mechanisms specific for functioning of proteins from organisms of different life domains. Mechanisms of SSB protein interactions with DNA during metabolism of the latter are studied; structural organization of the SSB protein complexes with DNA, as well as structural and functional peculiarities of different SSB proteins are analyzed.
Key wordsSSB proteins replication protein A protein-DNA complexes DNA replication DNA repair
amino acid residues
Escherichia coli SSB
Homo sapiens RPA
nucleotide excision repair
- OB domain
proliferating cell nuclear antigen
DNA polymerase α-primase complex
replication factor C
replication protein A
single-stranded DNA-binding protein
Unable to display preview. Download preview PDF.