Biochemistry (Moscow)

, Volume 73, Issue 13, pp 1388–1404

Mechanisms of single-stranded DNA-binding protein functioning in cellular DNA metabolism

Review

Abstract

This review deals with analysis of mechanisms involved in coordination of DNA replication and repair by SSB proteins; characteristics of eukaryotic, prokaryotic, and archaeal SSB proteins are considered, which made it possible to distinguish general mechanisms specific for functioning of proteins from organisms of different life domains. Mechanisms of SSB protein interactions with DNA during metabolism of the latter are studied; structural organization of the SSB protein complexes with DNA, as well as structural and functional peculiarities of different SSB proteins are analyzed.

Key words

SSB proteins replication protein A protein-DNA complexes DNA replication DNA repair 

Abbreviations

a.a.

amino acid residues

dsDNA

double-stranded DNA

ecoSSB

Escherichia coli SSB

hsRPA

Homo sapiens RPA

NER

nucleotide excision repair

nt

nucleotide

OB domain

oligosaccharide/oligonucleotide-binding domain

PCNA

proliferating cell nuclear antigen

pol-prim

DNA polymerase α-primase complex

RFC

replication factor C

RPA

replication protein A

SSB

single-stranded DNA-binding protein

ssDNA

single-stranded DNA

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Institute of Chemical Biology and Fundamental MedicineSiberian Branch of the Russian Academy of SciencesNovosibirskRussia

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