Biochemistry (Moscow)

, Volume 73, Issue 11, pp 1228–1234 | Cite as

Polyamine as a signaling molecule for controlling an adaptive mutation

  • Il Lae Jung
  • In Gyu KimEmail author


In the absence of exogenous polyamines, the polyamine-deficient Escherichia coli mutant shows not only a characteristic dual-phase growth with abnormal growth, growth arrest, and normal growth after mutation, but also a higher expression of the SOS genes than the polyamine-proficient wild type. The interval of the growth arrest is inversely regulated in a polyamine concentration-dependent manner. These results indicate that the polyamines can act as a signal not only for provoking an adaptive mutation, but also for hastening generation of an adaptive mutation.

Key words

adaptive mutation Escherichia coli mutational speed polyamine SOS response 



Luria-Bertani medium


phosphate-buffered saline


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Supplementary material

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Department of Radiation Biology, Environmental Radiation Research CenterKorean Atomic Energy Research InstituteYusong, DaejeonKorea

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