Advertisement

Biochemistry (Moscow)

, Volume 73, Issue 11, pp 1228–1234 | Cite as

Polyamine as a signaling molecule for controlling an adaptive mutation

  • Il Lae Jung
  • In Gyu KimEmail author
Article
  • 45 Downloads

Abstract

In the absence of exogenous polyamines, the polyamine-deficient Escherichia coli mutant shows not only a characteristic dual-phase growth with abnormal growth, growth arrest, and normal growth after mutation, but also a higher expression of the SOS genes than the polyamine-proficient wild type. The interval of the growth arrest is inversely regulated in a polyamine concentration-dependent manner. These results indicate that the polyamines can act as a signal not only for provoking an adaptive mutation, but also for hastening generation of an adaptive mutation.

Key words

adaptive mutation Escherichia coli mutational speed polyamine SOS response 

Abbreviations

LB

Luria-Bertani medium

PBS

phosphate-buffered saline

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Supplementary material

10541_2008_1108_MOESM1_ESM.pdf (197 kb)
Supplementary material, approximately 200 KB.

References

  1. 1.
    Bjed, I., Tenaillon, O., Gerard, B., Souza, V., Denamur, E., Radman, M., Taddei, F., and Matic, I. (2003) Science, 300, 1404–1409.CrossRefGoogle Scholar
  2. 2.
    Shankel, D. M., Hartman, P. E., Kada, T., and Hollaender, A. (1987) Environ. Mutagen., 9, 87–103.PubMedCrossRefGoogle Scholar
  3. 3.
    Strauss, B. S. (1998) Genetics, 148, 1619–1626.PubMedGoogle Scholar
  4. 4.
    Drake, J. W. (1991) Annu. Rev. Genet., 25, 125–146.PubMedCrossRefGoogle Scholar
  5. 5.
    Foster, P. L. (1993) Annu. Rev. Microbiol., 47, 457–504.CrossRefGoogle Scholar
  6. 6.
    Hall, B. G. (1992) Curr. Opin. Genet. Dev., 2, 943–946.PubMedCrossRefGoogle Scholar
  7. 7.
    Harris, R. S., Longerich, S., and Rosenberg, S. M. (1994) Science, 264, 258–260.PubMedCrossRefGoogle Scholar
  8. 8.
    Rosenberg, S. M., and Hastings, P. J. (2003) Science, 300, 1382–1383.PubMedCrossRefGoogle Scholar
  9. 9.
    Finch, C. E., and Goodman, M. F. (1997) Trends Neurosci., 20, 501–507.PubMedCrossRefGoogle Scholar
  10. 10.
    Foster, P. L. (1999) Annu. Rev. Genet., 33, 57–88.PubMedCrossRefGoogle Scholar
  11. 11.
    Rosenberg, S. M. (2001) Nat. Rev. Genet., 504–515.Google Scholar
  12. 12.
    Echols, H. (1981) Cell, 25, 1–2.PubMedCrossRefGoogle Scholar
  13. 13.
    Radman, M. (1975) Basic Life Sci., 5A, 355–367.PubMedGoogle Scholar
  14. 14.
    Geiger, L. E., and Morris, D. R. (1980) J. Bacteriol., 141, 1192–1198.PubMedGoogle Scholar
  15. 15.
    Jung, I. L., and Kim, I. G. (2003) J. Biol. Chem., 278, 22846–22852.PubMedCrossRefGoogle Scholar
  16. 16.
    Jung, I. L., and Kim, I. G. (2003) Cell. Biol. Toxicol., 19, 29–41.PubMedCrossRefGoogle Scholar
  17. 17.
    Jung, I. L., and Kim, I. G. (2003) Environ. Toxicol. Pharmacol., 15, 19–26.CrossRefGoogle Scholar
  18. 18.
    Jung, I. L., and Kim, I. G. (2003) Biochem. Biophys. Res. Commun., 301, 915–922.PubMedCrossRefGoogle Scholar
  19. 19.
    Jung, I. L., Oh, T. J., and Kim, I. G. (2003) Arch. Biochem. Biophys., 418, 125–132.PubMedCrossRefGoogle Scholar
  20. 20.
    Tkachenko, A. G., Nesterova, L., and Pshenichnov, M. (2001) Arch. Microbiol., 176, 155–157.PubMedCrossRefGoogle Scholar
  21. 21.
    Tkachenko, A. G., and Fedotova, M. V. (2007) Biochemistry (Moscow), 72, 109–116.CrossRefGoogle Scholar
  22. 22.
    Miller, J. H. (1972) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.Google Scholar
  23. 23.
    Friedberg, E. C., Walker, G. C., and Siede, W. (1995) American Society for Microbiology, Washington, DC.Google Scholar
  24. 24.
    Taddei, F., Halliday, J. A., Matic, I., and Radman, M. (1997) Mol. Gen. Genet., 256, 277–281.PubMedCrossRefGoogle Scholar
  25. 25.
    Fijalkowska, I. J., Dunn, R. L., and Schaaper, R. M. (1997) J. Bacteriol., 179, 7435–7445.PubMedGoogle Scholar
  26. 26.
    McMurry, L. M., and Algranati, I. D. (1986) Eur. J. Biochem., 155, 383–390.PubMedCrossRefGoogle Scholar

Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Department of Radiation Biology, Environmental Radiation Research CenterKorean Atomic Energy Research InstituteYusong, DaejeonKorea

Personalised recommendations