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Biochemistry (Moscow)

, Volume 73, Issue 9, pp 957–964 | Cite as

Aconitate hydratase of mammals under oxidative stress

  • L. V. MatasovaEmail author
  • T. N. Popova
Review

Abstract

Data on the structure, functions, regulation of activity, and expression of cytosolic and mitochondrial aconitate hydratase isoenzymes of mammals are reviewed. The role of aconitate hydratase and structurally similar iron-regulatory protein in maintenance of homeostasis of cell iron is described. Information on modifications of the aconitate hydratase molecule and changes in expression under oxidative stress is generalized. The role of aconitate hydratase in the pathogenesis of some diseases is considered.

Key words

aconitase citrate oxidative stress iron iron-regulatory proteins regulation of activity and expression 

Abbreviations

AH

aconitate hydratase

cAH

cytoplasmic aconitase isoenzyme

HRM

hemoregulatory motif

IL

interleukins

IRE

iron-sensitive elements

IRP

iron-regulatory proteins

LIP

labile iron pool

mAH

mitochondrial aconitase isoenzyme

MtFt

mitochondrial ferritin

ROS

reactive oxygen species

SOD

superoxide dismutase

TCA cycle

tricarboxylic acid cycle

TNF-α

tumor necrosis factor-α

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Voronezh State UniversityVoronezhRussia

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