Biochemistry (Moscow)

, Volume 73, Issue 7, pp 742–750 | Cite as

Changes in regulation of cell—cell adhesion during tumor transformation

  • N. A. GloushankovaEmail author


Cadherin-mediated cell—cell adhesion defines the integrity of most tissues. Cell—cell adherens junctions are dynamic structures whose functional state is regulated by interactions of cadherin with β-catenin, p120, and actin cytoskeleton structures. Small GTPases of the Rho family and GTPase Rap1 play the central role in the formation and maintenance of cell—cell adhesion. Aberrant activation of signaling pathways, transcriptional repression of the E-cadherin gene, ectopic expression of N-cadherin, and disturbances in regulation of adhesive and transcriptional functions of β-catenin stimulate tumor progression.

Key words

cell—cell adherens junctions cadherins actin cytoskeleton epithelial-mesenchymal transformation 



cell—cell adherens junctions


epidermal growth factor


epithelial-mesenchymal transformation


fibroblast growth factor


guanine nucleotide exchange factors


hepatocyte growth factor/scatter factor


platelet-derived growth factor


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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Blokhin Cancer Research CenterRussian Academy of Medical SciencesMoscowRussia

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