Biochemistry (Moscow)

, 73:669 | Cite as

Anti-inflammatory activity of polysaccharide from Pholiota nameko

  • Haiping LiEmail author
  • Xiaoxiang Lu
  • Shuhai Zhang
  • Meijun Lu
  • Hongmei Liu
Accelerated Publication


Pholiota nameko polysaccharide (PNPS-1) has been isolated and purified by enzymatic hydrolysis, hot water extraction, ethanol precipitation, and ion-exchange and gel-filtration chromatography. The anti-inflammatory activity of PNPS-1 was evaluated in rodents using xylene-induced ear edema, egg albumin-, carrageenin-, and formaldehyde-induced paw edema, cotton pellet granuloma test, adhesion of peritoneal leukocytes in vitro, and ulcerogenic activity. The results showed that PNPS-1 (5 mg/ear) inhibited topical edema in the mouse ear and at 100, 200, and 400 mg/kg (intraperitoneally) it significantly suppressed the development of egg albumin-, carrageenin-, and formaldehyde-induced paw edema in the animals. PNPS-1 (100, 200, and 400 mg/kg, per oral) significantly inhibited the growth of granuloma tissues induced by subcutaneously implanted cotton pellets in rats by 10.96, 18.07, and 43.75%, respectively. PNPS-1 also inhibited spontaneous and phorbol-12-myristate-13-acetate-activated adhesion of peritoneal leukocytes in vitro. Further, both acute as well as chronic administration of PNPS-1 (100, 200, and 400 mg/kg, per oral) did not produce any gastric lesion in rats. In conclusion, these data indicated that PNPS-1 possesses significant anti-inflammatory activity suggesting its potential as an anti-inflammatory agent for use in the treatment of various inflammatory-related diseases.

Key words

Pholiota nameko polysaccharide anti-inflammatory activity leukocyte adhesion 



acetylsalicylic acid


crude P. nameko polysaccharide




Pholiota nameko polysaccharide


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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • Haiping Li
    • 1
    Email author
  • Xiaoxiang Lu
    • 1
  • Shuhai Zhang
    • 1
  • Meijun Lu
    • 1
  • Hongmei Liu
    • 1
  1. 1.Tianjin Key Laboratory of Food Biotechnology, Faculty of Biotechnology and Food ScienceTianjin University of CommerceTianjinP. R. China

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