Biochemistry (Moscow)

, 73:605 | Cite as

Targeted therapy in the treatment of solid tumors: Practice contradicts theory

Review

Abstract

The basic principle of targeted therapy formulated about ten years ago consists in the design and application of drugs specifically directed against well-defined targets that are critical for tumor survival and not compromising for normal organs and tissues. The past decade has been marked by the appearance of an immense diversity of novel antitumor agents with claimed targeted action. Unfortunately, despite indisputable progress in clinical settings, some popular drugs against solid tumors (e.g. bevacizumab, trastuzumab, erlotinib, gefitinib) nominally assigned to targeted-action drugs, cannot actually be classified with this group being nonconforming to a priori stated goals of targeted therapy. The state-of-the-art and current problems in targeted therapy of solid tumors are reviewed.

Key words

targeted therapy breast cancer colorectal cancer VEGF VEGFR EGFR HER-2 

Abbreviations

CEP

circulating endothelial precursors

EGFR

epidermal growth factor receptor

HSC

hemopoietic stem cells

NSCLC

non-small cell lung cancer

VEGF

vasoen-dothelial growth factor

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Federal Research-Clinical Center for Pediatric Hematology, Oncology, and ImmunologyMinistry of Health Care and Social Security of the Russian FederationMoscowRussia
  2. 2.Blokhin Cancer Research CenterRussian Academy of Medical SciencesMoscowRussia

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