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Biochemistry (Moscow)

, Volume 73, Issue 5, pp 592–604 | Cite as

Transport proteins of the ABC family and multidrug resistance of tumor cells

  • A. A. Stavrovskaya
  • T. P. Stromskaya
Review

Abstract

Some new data concerning the role of transport proteins of the ABC family in multidrug resistance (MDR) of human tumor cells, and problems connected with regulation of these proteins are considered. MDR is a complex phenomenon that may be caused simultaneously by several mechanisms functioning in one and the same cell. Among them there may be the alterations of activity of several transport proteins. Activation of these proteins may be associated with alterations of activities of different cell protective systems and of the signal transduction pathways involved in regulation of proliferation, differentiation, and apoptosis. Clinical significance of multifactor MDR is discussed.

Key words

ABC family proteins P-glycoprotein multidrug resistance of tumors 

Abbreviations

AP

acceleration phase

CML

chronic myelogenous leukemia

CP

chronic phase

MDR

multidrug resistance

MDT

transporters of multiple drugs

NBD

nucleotide binding domains

Pgp

P-glycoprotein

PI3K

phosphoinosi-tol-3-kinase

PTEN

phosphatase and tensin homolog

Rh123

Rhodamine 123

RT-PCR

reverse transcription polymerase chain reaction

TMD

transmembrane binding domains

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Institute of Carcinogenesis, Blokhin Cancer Research CenterRussian Academy of Medical SciencesMoscowRussia

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