Biochemistry (Moscow)

, Volume 73, Issue 5, pp 592–604 | Cite as

Transport proteins of the ABC family and multidrug resistance of tumor cells

  • A. A. Stavrovskaya
  • T. P. Stromskaya


Some new data concerning the role of transport proteins of the ABC family in multidrug resistance (MDR) of human tumor cells, and problems connected with regulation of these proteins are considered. MDR is a complex phenomenon that may be caused simultaneously by several mechanisms functioning in one and the same cell. Among them there may be the alterations of activity of several transport proteins. Activation of these proteins may be associated with alterations of activities of different cell protective systems and of the signal transduction pathways involved in regulation of proliferation, differentiation, and apoptosis. Clinical significance of multifactor MDR is discussed.

Key words

ABC family proteins P-glycoprotein multidrug resistance of tumors 



acceleration phase


chronic myelogenous leukemia


chronic phase


multidrug resistance


transporters of multiple drugs


nucleotide binding domains






phosphatase and tensin homolog


Rhodamine 123


reverse transcription polymerase chain reaction


transmembrane binding domains


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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Institute of Carcinogenesis, Blokhin Cancer Research CenterRussian Academy of Medical SciencesMoscowRussia

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