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Biochemistry (Moscow)

, Volume 73, Issue 4, pp 393–405 | Cite as

Mammalian galectins: Structure, carbohydrate specificity, and functions

  • E. M. Rapoport
  • O. V. Kurmyshkina
  • N. V. BovinEmail author
Review

Abstract

Galectins are a family of β-galactoside binding lectins, homological by a sequence of the carbohydrate-binding site. In this review literature data about structure and carbohydrate specificity of galectins are discussed. The role of galectins in the regulation of cell adhesion in immune response, inflammation, and cancer progression is considered.

Key words

apoptosis galectins cell adhesion lactosamine carbohydrate specificity 

Abbreviations

CRD

carbohydrate-recognition domain

LacNAc

lactosamine

(LacNAc)n

where n > 1) oligolactosamine

LNnT

lactoneotetraose

Su

sulfate

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • E. M. Rapoport
    • 1
  • O. V. Kurmyshkina
    • 1
  • N. V. Bovin
    • 1
    Email author
  1. 1.Shemyakin and Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia

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