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Biochemistry (Moscow)

, 73:367 | Cite as

Mechanisms determining phenotypic heterogeneity of hepatocytes

  • I. F. UsyninEmail author
  • L. E. Panin
Review

Abstract

This review summarizes results of biochemical and immunohistochemical studies indicating the existence of functional heterogeneity of hepatocytes depending on their localization in the hepatic acinus; this determines characteristic features of metabolism of carbohydrates, lipids, and xenobiotics. The physiological significance of hepatocyte heterogeneity is discussed. According to the proposed model of intercellular communication, the metabolic specialization of hepatocytes is determined by secretory activity of hepatic resident macrophages (Kupffer cells) localized mainly in the periportal zone of the liver acinus. Macrophages participate in secretion of a wide spectrum of intercellular mediators (cytokines, prostaglandins, growth factors) and also in metabolism of numerous blood metabolites and biologically active substances (hormones, lipoproteins, etc.). In the sinusoid and in the space of Disse (also known as perisinusoidal space) they form a concentration gradient of regulatory factors and metabolites inducing the phenotypic differences between hepatocytes.

Key words

liver metabolism hepatocyte heterogeneity macrophage Kupffer cell intercellular communications 

Abbreviations

apo

apolipoprotein

CYP

cytochrome P450

EGF

epidermal growth factor

G6PDH

glucose-6-phosphate dehydrogenase

HDL

high density lipoproteins

HGF

hepatocyte growth factor

IGF

insulin-like growth factor

IGFBP

insulin-like growth factor binding protein

IL

interleukin

LAP

latency associated peptide

LDL

low density lipoproteins

LTBP

latent TGF-binding protein

MCT

3-methylcholanthrene

PAI-1

plasminogen activator inhibitor-1

PB

phenobarbital

PEPCK

phosphoenolpyruvate carboxykinase

TGF-β1

transforming growth factor-β1

TNF-α

tumor necrosis factor-α

VLDL

very low density lipoproteins

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© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Institute of BiochemistrySiberian Division of the Russian Academy of Medical SciencesNovosibirskRussia

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